Senior Industrial Engineering & Process Optimization Lead

Twistbioscience; Portland (OR); On-site; USD 140,000 - 190,000; Full time

Job summary

Twist Bioscience seeks a Sr Manager, Process Optimization & Industrial Engineering to lead continuous improvement across high-throughput manufacturing. You will apply IE methods to diagnose bottlenecks, model capacity, and build data-driven cases for process redesigns, equipment investments, or staffing changes.

This onsite role in Wilsonville, OR requires 8–12+ years in IE, a track record of leading teams, and experience in ISO 13485 or GMP/GxP environments.

Qualifications

• Bachelor’s or Master’s degree in Industrial/Mechanical/Manufacturing Engineering or related field.
• 8–12+ years in industrial engineering, continuous improvement, or manufacturing process optimization.
• 3–5+ years in a supervisory, management, or cross-functional leadership role.
• Demonstrated hands-on experience in ISO 13485 or GxP-regulated environments.
• Strong analytical foundation with OEE, Cpk, takt time, and cost-per-unit modeling.
• Proven ability to influence cross-functional stakeholders without direct authority over manufacturing execution.
• Hands-on expertise using core industrial engineering tools (time-motion studies, line balancing, capacity modeling, value stream mapping).

Responsibilities

• Analyze manufacturing line performance data to identify capacity constraints, turnaround time bottlenecks, and labor utilization inefficiencies across production processes.
• Investigate first pass rate losses and defect trends; lead root cause analysis efforts with Quality and Manufacturing to reduce rework, scrap, and reprocessing.
• Develop and prioritize a pipeline of improvement opportunities, evaluating whether process redesign, equipment/automation investment, or staffing changes offer the best return.
• Build business cases and ROI models for proposed improvements, including capital equipment requests, to support engineering and manufacturing leadership decision-making.
• Design and implement process changes using industrial engineering tools (time-motion studies, line balancing, value stream mapping, DOE) and validate improvements through structured pilots.
• Partner with Automation Engineering to scope opportunities where equipment or automation upgrades can address capacity, quality, or labor constraints.
• Collaborate with Manufacturing and Workforce Planning to right-size staffing models and improve labor efficiency without compromising quality or compliance.
• Establish and track key performance indicators (OEE, first pass yield, cycle time, cost-per-unit) to measure the impact of improvement initiatives over time.
• Ensure all process changes are executed in compliance with GxP requirements, working with Quality Assurance on change control and documentation.
• Present improvement roadmaps, project status, and results to senior engineering and manufacturing leadership.

Skills

OEE analysis

Cpk analysis

takt time

value stream mapping

DOE

time-motion studies

line balancing

ROI modeling

root cause analysis

data-driven decision making

statistical process improvement

Education

Bachelor’s or Master’s degree in Industrial Engineering or related technical field

Job description

Twist Bioscience seeks a Sr Manager, Process Optimization & Industrial Engineering to lead continuous improvement across high-throughput manufacturing. You will apply IE methods to diagnose bottlenecks, model capacity, and build data-driven cases for process redesigns, equipment investments, or staffing changes.

This onsite role in Wilsonville, OR requires 8–12+ years in IE, a track record of leading teams, and experience in ISO 13485 or GMP/GxP environments.