Senior Immunology Research Associate — Autoimmune RNA Biology

The Ohio State University; Columbus (OH); On-site; USD 80,000 - 110,000; Full time

Job summary

The Ohio State University invites applications for a Research Senior Associate in the Medicine | Pathology departments to study the immunopathogenesis of SLE, lupus nephritis, and RA. The role combines advanced immunology with RNA regulation and computational analyses to identify RNA-mediated pathways that drive immune dysregulation and tissue injury in autoimmune disease.

You will work with multi-omics approaches and murine models, publish in high‑impact journals, present findings at scientific

Qualifications

• Master's degree in Immunology or related field; PhD preferred.
• 3 years of relevant experience with Bachelor's, or 1 year with Master's.
• Strong immunology background and experience with RNA-seq data.

Responsibilities

• Investigate roles of T cells and dendritic cells in SLE, lupus nephritis, and RA.
• Define disease-associated immune cell states using transcriptomic, epigenomic, and spatial omics approaches.
• Integrate computational and experimental approaches to uncover mechanisms and therapeutic targets.
• Identify RNA regulatory networks and RNA-binding protein–mediated mechanisms that control immune activation and pathogenic function.
• Perform multi-parameter flow cytometry, intracellular cytokine staining, ELISAs, and T cell–dendritic cell co-culture assays.
• Execute murine autoimmune disease models.
• Assess disease outcomes including proteinuria, renal pathology, joint inflammation, autoantibody production, and immune cell phenotypes.
• Publish findings in high-impact journals, present at scientific meetings, mentor trainees, and contribute to grant applications.

Skills

T cell biology

Dendritic cell biology

Transcriptomic data analysis

Flow cytometry

FlowJo analysis

Immunological assays

Education

Master's degree in Immunology or related field

Ph.D. preferred

Tools

R

Python

Seurat

Scanpy

Job description

The Ohio State University invites applications for a Research Senior Associate in the Medicine | Pathology departments to study the immunopathogenesis of SLE, lupus nephritis, and RA. The role combines advanced immunology with RNA regulation and computational analyses to identify RNA-mediated pathways that drive immune dysregulation and tissue injury in autoimmune disease.

You will work with multi-omics approaches and murine models, publish in high‑impact journals, present findings at scientific