Research Senior Associate - Pathology

Ohio State University; United States; Vor Ort; USD 85.000 - 125.000; Vollzeit

Benefits dieser Stelle

Medical, dental and vision coverage

Paid time off

State retirement plan or employer-mro

Zusammenfassung

Ohio State University is seeking a Research Senior Associate in the Pathology Department to study the immunopathogenesis of SLE, lupus nephritis, and RA by integrating immune cell biology with RNA regulation and computational analysis.

The successful candidate will combine flow cytometry, transcriptomics, and functional assays to identify RNA-mediated pathways, publish findings, and mentor trainees while contributing to grant applications.

Qualifikationen

• Master's degree in immunology or related field; PhD preferred.
• 3 years of relevant experience with Bachelor's, or 1 year with Master's.
• Strong background in immunology, including T cell and dendritic cell biology.
• Experience with bulk RNA-seq and/or single-cell RNA-seq transcriptomics.
• Demonstrated research publications in immunology, RNA biology, genomics, or autoimmune disease.
• Experience with multi-color flow cytometry and FlowJo analysis.
• Proficiency in immunological assays.

Aufgaben

• Investigate roles of T cells and dendritic cells in SLE, lupus nephritis, and RA.
• Define disease-associated immune states and molecular pathways using transcriptomic, epigenomic, and spatial omics approaches.
• Integrate computational and experimental approaches to uncover mechanisms and targets.
• Identify RNA regulatory networks and RNA‑binding protein mechanisms.
• Perform multi-parameter flow cytometry, intracellular cytokine staining, ELISAs, and T cell–dendritic cell co-culture assays.
• Execute murine autoimmune disease models.
• Assess disease outcomes including proteinuria, renal pathology, joint inflammation, autoantibody production, and immune phenotypes.
• Publish findings in high-impact journals and contribute to grant applications.

Kenntnisse

Immunology

T cell biology

Flow cytometry

RNA‑seq

Single-cell RNA‑seq

Bioinformatics

Ausbildung

Master's degree in Immunology, Molecular Biology, Genetics, Computational Biology, or related field

Ph.D. preferred

Tools

FlowJo

R

Python

Seurat

Scanpy

Jobbeschreibung

Job Title

Research Senior Associate - Pathology Department: Medicine | Pathology

Position Summary

We are seeking a highly motivated researcher to investigate the immunopathogenesis of systemic lupus erythematosus (SLE), lupus nephritis, and rheumatoid arthritis (RA) through the integrated study of immune cell function and RNA regulatory mechanisms. The successful candidate will combine advanced immunological approaches with genomic and computational analyses to identify RNA-mediated pathways that drive immune dysregulation, kidney inflammation, and tissue injury in autoimmune disease.

Responsibilities

• Investigate the roles of T cells and dendritic cells in SLE, lupus nephritis, and RA
• Define disease-associated immune cell states and molecular pathways using transcriptomic, epigenomic, and spatial omics approaches
• Integrate computational and experimental approaches to uncover biologically actionable mechanisms and therapeutic targets
• Identify RNA regulatory networks and RNA‑binding protein–mediated mechanisms that control immune cell activation, differentiation, and pathogenic function
• Perform multi-parameter flow cytometry, intracellular cytokine staining, ELISAs, and T cell‑dendritic cell co‑culture assays
• Execute murine autoimmune disease models
• Assess disease outcomes including proteinuria, renal pathology, joint inflammation, autoantibody production, and immune cell phenotypes
• Publish findings in high-impact journals, present at scientific meetings, mentor trainees, and contribute to grant applications

Required Qualifications

• Master's Degree in Immunology, Molecular Biology, Genetics, Computational Biology, Bioinformatics, or a related field or equivalent experience required. Ph.D. preferred.
• 3 years of relevant experience required with Bachelor's Degree, or 1 year of relevant experience required with Master's Degree.
• Strong background in immunology, including T cell biology and dendritic cell biology.
• Experience with transcriptomic data analysis, including bulk RNA‑seq and/or single-cell RNA‑seq.
• Demonstrated research productivity with peer‑reviewed publications in immunology, RNA biology, genomics, or autoimmune disease.
• Experience with multi‑color flow cytometry, immune phenotyping, and FlowJo analysis.
• Proficiency in immunological assays.

Preferred Qualifications

• Expertise in RNA biology, RNA‑binding proteins, post‑transcriptional gene regulation, alternative splicing, or non‑coding RNAs.
• Experience with single‑cell multi‑omics, ATAC‑seq, spatial transcriptomics, and integrative computational analyses.
• Experience with murine autoimmune disease models and immune cell isolation.
• Proficiency in R, Python, Seurat, Scanpy, or related bioinformatics tools.
• Experience with adoptive transfer, bone marrow chimeras, spectral flow cytometry, CyTOF, or humanized mouse models.

Additional Information

Location: Tzagournis Medical Research Facility (0163)

Position Type: Regular

Scheduled Hours: 40

Shift: First Shift

Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.

Equal Opportunity Employer

The university is an equal opportunity employer, including veterans and disability.

Benefits

Ohio State benefits give you options to take care of what matters most to you — and opportunities to make adjustments as your life and needs change, including:

• Medical, dental and vision coverage, with Ohio State paying a significant portion of the cost.
• Paid time off, including sick and vacation time and 11 holidays.
• State retirement plan or an alternative retirement plan, both with generous employer contributions.

About Ohio State

As Buckeyes, we accomplish more together. No matter your role, you’ll be part of creating what people need now: pathways to education, research and health care. Working at Ohio State means you’re part of a team with a strong sense of community and an unwavering commitment to excellence — and, of course, incomparable Buckeye spirit. We bring out the best in people, help each other succeed and learn together. By joining Ohio State, you become part of a top‑20 public university with one of America’s leading academic health centers. We’re a team of dedicated colleagues with access to boundless resources that support you.