Senior Immuno-Oncology Scientist — In Vivo Lead

APTEVO BIOTHERAPEUTICS LLC; Seattle (WA); On-site; USD 137,000 - 191,000; Full time

Benefits offered by this job

Generous PTO program

Medical and dental insurance for you

401(k) match program

Life and AD&D insurance

Job summary

APTEVO BIOTHERAPEUTICS LLC is seeking a Senior Scientist for a 6-month contracted role in Immunobiology, to lead design and execution of humanized in vivo experiments evaluating novel protein therapeutics in oncology.

The role requires extensive immunology expertise, experience coordinating across functions, and a track record of independent project leadership. Responsibilities include in vivo efficacy studies and collaboration with CROs and academic partners.

Qualifications

• PhD or equivalent with extensive oncology immunology research experience.
• Experience with IACUC and animal handling
• Experience with cellular and protein immunoassays (multiplex cytokines, FACS)

Responsibilities

• Design and conduct humanized in vivo models for oncology molecules.
• Oversee efficacy studies using rodent cancer models.
• Culture of mammalian tumor cells.
• Implantation of tumor xenografts in mice (subcutaneous/orthotopic).
• Administer compounds and collect samples for tumor assessment.
• In vivo imaging to monitor tumor burden and response.
• Ex vivo efficacy studies with human cells/samples.
• Evaluate in vitro activity against oncology targets.
• Investigate mechanism of action and toxicity.
• Ex vivo analysis of cells from in vivo studies.
• Prepare protocols and reports for scientific communication.
• Assist in selecting and managing academic and CRO collaborations.
• Provide pre-clinical data to support IND-enabling activities.

Skills

Immunology expertise

Independent project leadership

Cross-functional collaboration

Strong communication

In vivo experimentation

Education

PhD in biological sciences

MS/MA with 13+ years experience

BS/BA with 15+ years experience

Job description

APTEVO BIOTHERAPEUTICS LLC is seeking a Senior Scientist for a 6-month contracted role in Immunobiology, to lead design and execution of humanized in vivo experiments evaluating novel protein therapeutics in oncology.

The role requires extensive immunology expertise, experience coordinating across functions, and a track record of independent project leadership. Responsibilities include in vivo efficacy studies and collaboration with CROs and academic partners.