Senior Full-Stack Engineer — Genomics Platform

Broad Institute of MIT and Harvard; Cambridge (MA); Hybrid; USD 108,000 - 150,667; Full time

Job summary

Broad Institute of MIT and Harvard in Cambridge, MA invites a Senior Software Engineer, Full Stack to join the Translational Genomics Group, contributing to seqr platform used internationally to search large genomic datasets.

You will work across full stack—cloud deployments, data pipelines, back-end APIs, databases, and UI—starting with well-scoped tasks and gaining ownership over time. The team values independence and responsible use of AI-assisted tools.

Qualifications

• Requires 5+ years of related experience with a Bachelor’s degree in a related discipline; or 3+ years and a Master’s degree.
• Full‑stack experience across backend, database, and frontend layers.
• Strong Python and JavaScript skills.
• Ability to work independently and manage your own time effectively.
• Open to AI-assisted development tools with responsible handling of sensitive data.
• Strong communication skills and ability to collaborate with non-technical stakeholders.

Responsibilities

• Develop features across the full platform: data pipelines (Python/Hail), backend services (Python/Django), databases (PostgreSQL, ClickHouse), and frontend interfaces (React, Redux).
• Assist with deployment related troubleshooting and maintenance.
• Work independently on assigned tasks, growing in scope and complexity over time.
• Collaborate with the lead software engineer on design and architecture, expanding scope as you gain experience.
• Maintain and extend data pipelines that ingest genomic data and load them into analytical databases.
• Build and improve user interfaces that help researchers find disease-causing variants.
• Write tests, participate in code review, and contribute to CI/CD workflows.
• Collaborate with computational biologists, clinicians, and researchers to translate requirements into well-engineered solutions.

Skills

Python

JavaScript

Full-stack

Independent work

Communication

AI-assisted development

Education

Bachelor’s degree in a related discipline

Master’s degree

PhD considered

Tools

Python/Django

JavaScript/React

PostgreSQL

ClickHouse

GCP

Hail

Docker/Terraform/Helm

Bash/Unix/Linux

Git

Job description

Broad Institute of MIT and Harvard in Cambridge, MA invites a Senior Software Engineer, Full Stack to join the Translational Genomics Group, contributing to seqr platform used internationally to search large genomic datasets.

You will work across full stack—cloud deployments, data pipelines, back-end APIs, databases, and UI—starting with well-scoped tasks and gaining ownership over time. The team values independence and responsible use of AI-assisted tools.