Senior/Executive Director, Business Operations

BridgeBio; San Francisco (CA); On-site; USD 249,000 - 330,000; Full time

Benefits offered by this job

Hybrid work model

Employee Stock Purchase Program (ESPP)

Pre-tax commuter benefits

Competitive compensation

Job summary

BridgeBio is seeking a Senior/Executive Director, Business Operations for the Encaleret program in California. The role focuses on shaping strategic direction, forecasting, and commercialization readiness, partnering with cross-functional teams to drive long-term success.

Based in SF or Palo Alto, this position requires strong financial modeling skills, executive communication, and a track record in biotech strategy. The role offers a comprehensive rewards package and hybrid work considerations.

Qualifications

• MBA/MD/PhD or equivalent preferred.
• Strong analytical and strategic mindset.
• Proven experience in commercialization and partnering in life sciences.

Responsibilities

• Shape and guide strategic direction and resource allocation for Encaleret.
• Prepare executive-level presentations and market analyses for stakeholders.
• Oversee budget planning and long-term lifecycle management.
• Collaborate with R&D, Regulatory, Finance, Commercial, and Operations.

Skills

Strategic planning

Executive communication

Financial modeling

DCF modeling

Cross-functional leadership

Biotech/Pharma knowledge

Education

MBA / MD / PhD

Job description

Mavericks Wanted

When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on

Mavericks Wanted

When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on

In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allowsscience and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work.

What You'll Do

As the Senior/Executive Director, Business Operations, you will play a key role in shaping the future direction of our Encaleret program. You will lead strategic planning efforts and provide critical insights that influence high-impact decisions. Your expertise will help guide commercial launch readiness, modeling & forecasting, preparation of corporate materials intended for presentation, corporate development, and strategic activities. You will also partner closely with cross-functional teams, including supply chain and operations, to ensure strategic alignment. Your analytical skills and industry experience will directly contribute to the company's long-term success.

Responsibilities

Strategic Planning and Execution

• Shape and communicate the company's strategic direction through well-structured presentations that guide prioritization and resource allocation
• Lead strategic analyses for program evaluation, including discounted cash flow modeling, and secondary research (e.g., analogs research, epidemiology, claims data analysis)
• Prepare a strategy to guide the successful US commercialization of encaleret

Stakeholder Communication

• Develop and deliver executive-level presentations that effectively communicate strategic insights, corporate initiatives, and market analyses
• Create high-quality visual materials for partnership dialogue, Board of Directors meetings, investor discussions & communications, and internal alignment efforts
• Ensure presentations are tailored to the audience, synthesizing technical and business content into clear, concise, and actionable messaging
• Present and discuss findings of strategic analyses to a variety of audiences, including the Calcilytix team, leadership, and investors
• Support corporate development and partnering strategy to ensure that Encaleret can be accessed by eligible patients worldwide

Operational Excellence

• Oversee budget planning initiatives and ownership of long-term lifecycle planning

Cross-functional Partnership

• Collaborate with R&D, Regulatory, Finance, Commercial, and Operations to ensure holistic strategy development
• Collaborate with functional experts as a strategic partner to support the clinical and commercial success of Encaleret
• Collaborate with the BridgeBio commercial team and oversee research in pricing and reimbursement
• Lead or contribute to special initiatives involving product lifecycle planning, global expansion, or operational efficiency

Where You'll Work

This role requires in-office collaboration at least 3-4x per week in our San Francisco or Palo Alto Office.

Who You Are

• A higher degree or equivalent, such as an M.B.A., M.D., or Ph.D., is preferred
• 2-5 years of professional experience in management consulting (life sciences preferred), post-Series A investing, investment banking, venture capital, equity research, and/or corporate role in a therapeutics company
• Prior experience contributing to new product commercialization is a plus
• Proven scientific acumen, communication skills, and an analytical mindset
• A passion for helping patients
• Proficiency in financial modeling, particularly DCF models
• Tenure-appropriate understanding of the drug development life science and operating model. Understands how value is created across the lifespan of a molecule from discovery to commercial execution
• Tenure-appropriate understanding of the biotech landscape
• Exceptional written communication and presentation skills

At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states.

Salary

$249,000 - $330,000 USD

As a global company, our comprehensive benefits may vary based on location. We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return.

For BridgeBio Full-Time U.S Based Roles

Financial & Rewards

• Market-leading compensation
• 401(k) with employer match
• Employee Stock Purchase Program (ESPP)
• Pre-tax commuter benefits (transit and parking)
• Referral bonus for hired candidates
• Subsidized lunch and parking on in-office days

Health & Well-Being

• 100% employer-paid medical, dental, and vision premiums for you and your dependents
• Health Savings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA)
• Fertility & family-forming benefits
• Expanded mental health support (therapy and coaching resources)
• Hybrid work model with flexibility
• Flexible, “take-what-you-need” paid time off and company-paid holidays
• Comprehensive paid medical and parental leave to care for yourself and your family

Skill Development & Career Paths

• People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility
• We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching
• We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities