Senior Engineer: Mathematical Modeling and Simulation

Amgen Inc. (IR); Cambridge (MA); On-site; USD 115,000 - 156,000; Full time

Benefits offered by this job

Retirement plan and 401(k)

Medical/dental/vision coverage

Bonus program

Stock-based incentives

Job summary

Amgen Inc. (IR) is seeking a Senior Engineer to develop and manage finite element models of combination product devices, leveraging explicit and nonlinear FEM to enable robust design and process understanding.

The role emphasizes building trustworthy in-silico assets, applying physics-based and data-driven approaches, and guiding decision making across multi-functional teams. You will mentor other simulation experts, communicate model scope clearly, and support lifecycle management from concept

Qualifications

• PhD or MS with engineering experience in FEM modeling and simulation.
• Experience with explicit FEM modelling and non-linear structural modelling.
• Ability to develop in-silico models addressing device design, manufacturing, and lifecycle considerations.
• Familiarity with regulatory requirements for medical devices and design controls.

Responsibilities

• Implement explicit and implicit FEM structural models for drug delivery devices.
• Ensure modelling approach accurately represents the physical system.
• Apply engineering principles to create robust in-silico models.
• Continuously improve models and manage model lifecycle and backlog.
• Communicate modelling scope and limitations to stakeholders.
• Mentor other simulation experts in best practices.

Skills

FEM modelling

Python

MATLAB

Non-linear structural modelling

Scripting (Tcl/Tk)

Communication

Problem solving

Education

Doctorate degree

Master’s degree in Engineering

Bachelor’s degree in Engineering

High school diploma / GED with extensive experience

Tools

SIMULIA

ANSYS

ALTAIR

COMSOL

abaqus user subroutines

Tcl/Tk

Job description

Senior Engineer Mathematical Modeling and Simulation

Join Amgens Mission of Serving Patients At Amgen, if you feel like you are part of something bigger, it is because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we have helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas - Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you will help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you will thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

What you will do

Let’s do this. Let’s change the world.

Amgens Combination Product Operations Digital and Data Strategies group is a process development team that develops and deploys innovative advanced simulation technologies towards improved process understanding, robustness and monitoring, and prediction and optimization of the manufacturing of combination products. In this vital role you will support the team by incorporating physics and empirical techniques to develop rigorous finite element models (FEM) and numerical models of drug delivery devices (in-silico modeling assets) and improving the way Amgen manages and uses in-silico models to enhance decision making within the organization. The candidate will apply engineering principles to develop efficient and trustworthy models addressing a wide variety of challenging problems associated with advanced material modelling, device design, characterization, verification, validation, manufacturing and tolerance analysis. The ideal candidate enjoys tackling challenges and excels at developing functional in-silico models of combination products that enable insights for root cause investigation and design robustness supporting lifecycle management activities and complaint reduction.

Responsibilities

• Implementing explicit and implicit FEM structural models.
• Ensuring that the approach and simplifications used to build these models is efficiently representing the physical system.
• Applying engineering principles like kinematic, structural, and tolerance analysis combined with material characterization and testing to create in-silico models able to capture the behavior of the device during use, assembly and transport.
• Continuous improvement of in-silico models, managing the lifecycle of the model and improving methods and workstreams to guarantee efficiency and trustworthiness of the models.
• Demonstrating critical and analytical thinking skills to explore new opportunities in in-silico and data-driven computational models.
• Modeling real-world scenarios with the adequate level of detail and help inform the decision making in a reduced time frame.
• Simulate complaints and real-world issues within lifecycle of combination products.
• Being able to apply an analytical approach to create models that accurately represent the real world scenarios and helps identify the root cause analysis of any complaint.
• Providing positive leadership and delivering work in a fast-paced, multi-project, cross-functional environment.
• Delivering predictions and insight on time to solve challenging production and customer problems.
• Model ownership, responsible for developing and managing backlog of in-silico product projects.
• Being able to concisely communicate on the modelling scope, limitations and assumptions to stakeholders with a technical and not technical background.
• Mentor also other simulation experts in the best use of simulation technologies.

What we expect of you

Basic Qualifications

• Doctorate degree OR Master’s degree and 2 years of Engineering experience OR Bachelor’s degree and 4 years of Engineering experience OR Associate’s degree and 8 years of Engineering experience Or High school diploma / GED and 10 years of Engineering experience

Preferred Qualifications

• Finite element model experience with a commercial platform like SIMULIA, ANSYS, ALTAIR or COMSOL.
• Experience in explicit FEM modelling and non-linear structural models; contact modelling, large deformations, plasticity, and hyperelasticity.
• Knowledge of statistic and robustness analysis principles, being able to create models capturing the inherent variability in the process and device dimensions.
• Skilled in programming in Python, and/or MATLAB for engineering purposes.
• Scripting using commercial software codes like abaqus user subroutines, Tcl/Tk to automate model creation and post/processing.
• Experience with combination products and device regulatory requirements, medical device development and design controls, and knowledge of process controls.
• Excellent communication, presentation, and technical documentation skills are highly desired.
• Intellectual curiosity with ability to learn new concepts/frameworks, algorithms, and technology rapidly as needs arise.
• Ability to manage multiple competing priorities simultaneously and work in highly collaborative, cross-functional environments.

What you can expect of us

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions
• group medical, dental and vision coverage
• life and disability insurance
• flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible.

Sponsorship

Sponsorship for this role is not guaranteed.

Equal Opportunity Employer

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Salary Range 115,494.60USD -156,257.40 USD

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve peoples lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the worlds leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. For more information, visit www.amgen.com and follow us on www.twitter.com/amgen.