Senior Engineer: Mathematical Modeling and Simulation

Biopharma Careers; Cambridge (MA); On-site; USD 115,000 - 156,000; Full time

Job summary

Amgen in Cambridge, MA is seeking a Senior Engineer for Mathematical Modeling and Simulation to join the Combination Product Operations Digital and Data Strategies group. You will develop and deploy in-silico models of drug delivery devices using FEM and numerical methods to support robust design and decision making.

The role emphasizes collaboration across teams, model ownership, and mentoring others, with a focus on risk reduction, lifecycle management, and documenting the technical basis of

Qualifications

• PhD or equivalent required; multiple routes listed.
• Master’s degree and 2 years of engineering experience.
• Bachelor’s degree and 4 years of engineering experience.
• Associate’s degree and 8 years of engineering experience.
• High school diploma / GED and 10 years of engineering experience.

Responsibilities

• Implement explicit and implicit FEM structural models with efficient representations.
• Use kinematic, structural, and tolerance analysis to create in-silico models.
• Improve models, manage model life cycle and methods for trustworthiness.
• Model real-world scenarios to inform design decisions in short timeframes.
• Simulate complaints and issues to identify root causes in product lifecycle.
• Provide leadership and collaborate in fast-paced, multi-project environments.
• Own model backlog and communicate scope and assumptions to stakeholders.
• Lead and document the technical basis of models for broader teams.

Skills

Communication skills

Education

Doctorate degree

Master’s degree

Bachelor’s degree

Associate’s degree

High school diploma / GED

Tools

SIMULIA

ANSYS

ALTAIR

COMSOL

Python

MATLAB

ABAQUS scripting

Job description

Career Category

Engineering

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission, to serve patients living with serious illnesses, drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Engineer Mathematical Modeling and Simulation

What you will do

Let’s do this. Let’s change the world. Amgen's Combination Product Operations Digital and Data Strategies group is a process development team that develops and deploys innovative advanced simulation technologies towards improved process understanding, robustness and monitoring, and prediction and optimization of the manufacturing of combination products.

In this vital role you will support the team by incorporating physics and empirical techniques to develop rigorous finite element models (FEM) and numerical models of drug delivery devices (in-silico modeling assets) and improving the way Amgen manages and uses in-silico models to enhance decision making within the organization.

The candidate will apply engineering principles to develop efficient and trustworthy models addressing a wide variety of challenging problems associated with advanced material modelling, device design, characterization, verification, validation, manufacturing and tolerance analysis.

The ideal candidate enjoys tackling challenges and excels at developing functional in-silico models of combination products that enable insights for root cause investigation and design robustness supporting lifecycle management activities and complaint reduction.

Responsibilities

• Implementing explicit and implicit FEM structural models. Ensuring that the approach and simplifications used to build these models is efficiently representing the physical system.


• Applying engineering principles like kinematic, structural, and tolerance analysis combined with material characterization and testing to create in-silico models able to capture the behavior of the device during use, assembly and transport.


• Continuous improvement of in-silico models, managing the lifecycle of the model and improving methods and workstreams to guarantee efficiency and trustworthiness of the models.


• Demonstrating critical and analytical thinking skills to explore new opportunities in in-silico and data-driven computational models. Modeling real-world scenarios with the adequate level of detail and help inform the decision making in a reduced time frame.


• Simulate complaints and real-world issues within lifecycle of combination products. Being able to apply an analytical approach to create models that accurately represent the real world scenarios and helps identify the root cause analysis of any complaint.


• Providing positive leadership and delivering work in a fast-paced, multi-project, cross-functional environment. Delivering predictions and insight on time to solve challenging production and customer problems.


• Model ownership, responsible for developing and managing backlog of in-silico product projects. Being able to concisely communicate on the modelling scope, limitations and assumptions to stakeholders with a technical and not technical background. Mentor also other simulation experts in the best use of simulation technologies.


• It is expected that the Senior Engineer – Modeling and Simulation will not only lead and collaborate heavily with internal team members, but also document and communicate the underlying technical basis of the models for the benefit of and use by the broader engineering and scientific community responsible for design and manufacture of drug delivery devices.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Engineer professional we seek is an individual with these qualifications.

Basic Qualifications

• Doctorate degree


• OR


• Master’s degree and 2 years ofEngineeringexperience


• OR


• Bachelor’s degree and 4 years ofEngineeringexperience


• OR


• Associate’s degree and 8 years ofEngineeringexperience


• OR


• High school diploma / GED and 10 years ofEngineeringexperience

Preferred Qualifications

• Finite element model experience with a commercial platform like SIMULIA, ANSYS, ALTAIR or COMSOL.


• Experience in explicit FEM modelling and non-linear structural models; contact modelling, large deformations, plasticity, and hyperelasticity.


• Knowledge of statistic and robustness analysis principles, being able to create models capturing the inherent variability in the process and device dimensions.


• Skilled in programming in Python, and/or MATLAB for engineering purposes. Scripting using commercial software codes like abaqus user subroutines, Tcl/Tk to automate model creation and post/processing.


• Experience with combination products and device regulatory requirements, medical device development and design controls, and knowledge of process controls.


• Excellent communication, presentation, and technical documentation skills are highly desired.


• Intellectual curiosity with ability to learn new concepts/frameworks, algorithms, and technology rapidly as needs arise.


• Ability to manage multiple competing priorities simultaneously and work in highly collaborative, cross-functional environments.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts


• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan


• Stock-based long-term incentives


• Award-winning time-off plans


• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Sponsorship

Sponsorship for this role is not guaranteed.

Equal Opportunity and Accommodation

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

. Salary Range

115,494.60USD -156,257.40USD