Senior Downstream Process Engineer - Startup & Commissioning

Piper Companies; Cary (NC); On-site; USD 175,000 - 190,000; Full time

Job summary

Piper Companies seeks a Downstream Equipment Engineer to support startup and commissioning of a new commercial-scale biopharmaceutical facility. This role provides technical leadership for downstream purification startup efforts, ensuring equipment readiness, process validation, technology transfer, and operational excellence.

Responsibilities include collaborating with Manufacturing, MSAT, Validation, Quality, and Engineering teams to transfer processes for commercial readiness, and offering

Qualifications

• Bachelor's degree in Chemical Engineering or related field.
• 7+ years of downstream bioprocessing experience in GMP manufacturing.
• Experience with chromatography, filtration, and purification processes.
• Experience supporting startup, commissioning, or process validation desirable.
• Strong troubleshooting and cross-functional collaboration skills.

Responsibilities

• Support qualification, and startup of downstream processing equipment and systems.
• Lead troubleshooting and optimization of chromatography skids and columns.
• Partner with Manufacturing, MSAT, Validation, Quality, and Engineering teams to ensure successful process transfer and commercial readiness.
• Provide on-floor technical support/troubleshooting support during engineering, validation, and commercial manufacturing campaigns.
• Author and review SOPs, batch records, protocols, and technical reports.

Skills

Troubleshooting

Cross-functional collaboration

Communication

Leadership

Education

Bachelor's degree in Chemical Engineering, Biochemical Engineering, Biotechnology, or related field

Job description

Piper Companies seeks a Downstream Equipment Engineer to support startup and commissioning of a new commercial-scale biopharmaceutical facility. This role provides technical leadership for downstream purification startup efforts, ensuring equipment readiness, process validation, technology transfer, and operational excellence.

Responsibilities include collaborating with Manufacturing, MSAT, Validation, Quality, and Engineering teams to transfer processes for commercial readiness, and offering