Senior Director Program Management

Mantell Associates; Massachusetts; On-site; USD 119,510 - 179,850; Full time

Job summary

A leading biotechnology recruiting firm seeks a Senior Director of Program Management to drive advanced cell and gene therapy programs. The role requires leading cross-functional teams, strategic oversight of project timelines, and collaboration with external partners to ensure successful program execution. Ideal candidates will have extensive biotech experience and advanced degrees.

Qualifications

• 10+ years of experience in biotech/pharmaceutical industry.
• Strong expertise in cell and/or gene therapy.
• Proven track record in leading cross-functional drug development teams.

Responsibilities

• Lead cross-functional program teams in the development of advanced therapies.
• Develop comprehensive program plans including timelines and budgets.
• Ensure compliance with corporate strategy and financial targets.

Skills

Leadership

Strategic Planning

Communication

Project Management

Team Coordination

Education

PhD, PharmD, MD, or MS in life sciences

MBA (preferred)

Tools

MS Project

Smartsheet

Project Planning Software

Job description

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Associate at Mantell Associates | CGT Specialist Headhunter

Mantell Associates is partnered with an innovative Cell & Gene Therapy organisation, who is seeking an experienced Senior Director of Program Management to lead cross-functional program teams in the development of advanced cell and/or gene therapy programs.

The successful candidate will be responsible for driving strategic planning, execution, and delivery of complex projects across research, CMC, clinical, regulatory, and commercial functions. This is a high-impact role requiring leadership, strategic insight, and deep understanding of the biotech product development lifecycle.

Senior Director of Program Management - Responsibilities:

• Lead cross-functional program teams including R&D, CMC, regulatory, clinical, commercial, and business development
• Develop and maintain comprehensive program plans, timelines, budgets, and risk management strategies
• Act as the primary point of contact for program-level communication and updates to executive leadership and stakeholders
• Ensure alignment with corporate strategy, milestones, and financial targets
• Coordinate with CMC, clinical operations, and regulatory affairs to drive IND/CTA submissions, clinical trials, and BLA/MAA readiness
• Manage external partnerships including CROs, CDMOs, academic collaborators, and licensing partners
• Drive decision-making through well-prepared governance presentations and scenario planning
• Anticipate and mitigate program risks and interdependencies
• Maintain program documentation and ensure compliance with internal governance and regulatory expectations

Senior Director of Program Management - Requirements:

• Advanced degree in life sciences (PhD, PharmD, MD, or MS); MBA is a plus
• 10+ years of experience in biotech/pharmaceutical industry, including 5+ years of program management experience
• Deep expertise in cell and/or gene therapy, including understanding of vector manufacturing, regulatory landscape, and clinical development nuances
• Experience with rare diseases, oncology, or immunotherapy indications preferred
• Previous success in global development programs, including FDA and EMA interactions preferred
• PMP certification or formal project management training preferred
• Proven track record in leading cross-functional drug development teams from preclinical through clinical and ideally into commercialization
• Strong leadership, interpersonal, and influencing skills across matrixed organizations
• Excellent communication, presentation, and organizational skills
• Experience with tools like MS Project, Smartsheet, or other project planning software

Mantell Associates is a specialist Pharmaceutical and Life Science headhunting firm. For more information on this opportunity, contact us at [phone].

Seniority level

• Seniority level

  Director

Employment type

• Employment type

  Full-time

Job function

• Job function

  Management, Project Management, and Research

• Industries

  Biotechnology Research, Pharmaceutical Manufacturing, and Medical Equipment Manufacturing

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