Senior Director, Manufacturing Operations

Immatics; Houston (TX); On-site; USD 190,000 - 230,000; Full time

Job summary

Immatics is seeking a Senior Director of Manufacturing Operations to provide strategic and operational leadership for GMP manufacturing and MSAT activities supporting late-stage clinical development, regulatory approvals, and commercial supply of cell and gene therapy products. The role reports to the Site Head, Immatics US & VP of Technical Operations and is based at Stafford, TX.

This leadership position requires deep expertise in cGMP manufacturing, quality systems, process validation, and

Qualifications

• Bachelor’s in Immunology, Biochemistry, Cell Biology, Biotechnology, Bioengineering, or Pharmaceutical Sciences.

Responsibilities

• Lead, develop, and mentor a GMP Operations organization, driving accountability, collaboration, and continuous improvement.

Skills

GMP ops leadership

Manufacturing strategy

Tech transfer

Process validation

MSAT

Lean Six Sigma

S&OP

Data-driven decisions

Education

Bachelor's in Immunology/Biochemistry/Biotech

Master's or PhD in a relevant field

Tools

MES

ERP

LIMS

Statistical process monitoring

Job description

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME , a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Why Join Us?

• Innovative Environment: Help to pioneer advancements in cancer immunotherapy.
• Collaborative Culture: Be part of a diverse team dedicated to your professional growth.
• Global Impact: Contribute to therapies that make a lasting impact on patients globally.

Role Overview

The Senior Director, Manufacturing Operations provides strategic and operational leadership for GMP manufacturing and manufacturing sciences activities supporting late-stage clinical development, regulatory approval, commercial launch readiness, and routine commercial supply of cell and gene therapy products. The role translates CMC strategy into integrated execution across Manufacturing, MSAT, Technical Training, Recipe/Document Development, and Digital Manufacturing Systems.

Schedule: Monday-Friday, 1st Shift with weekends and holidays as needed

Reports to : Site Head, Immatics US & Vice President, Technical Operations

Location : Onsite, 13203 Murphy Road Suite 100 Stafford, TX 77477

Basic Qualifications:

• Bachelors in a relevant discipline such as Immunology, Biochemistry, Cell Biology, Biotechnology, Bioengineering, or Pharmaceutical Sciences.
• 15+ years of progressive Technical Operations or Manufacturing Operations experience including 5+ years direct management in cell therapy manufacturing leadership and strategy in industry setting.

Preferred Qualifications:

• Masters or Ph.D in a relevant discipline such as Immunology, Biochemistry, Cell Biology, Biotechnology, Bioengineering, or Pharmaceutical Sciences.
• Proven leadership experience supporting late-stage development through commercial manufacturing, including process validation, regulatory submissions, inspection readiness, commercial launch readiness, and ongoing manufacturing operations.
• Deep expertise in cGMP manufacturing, quality systems, and global regulatory requirements for biologics, cell and gene therapy, or other advanced therapy products.
• Demonstrated success leading manufacturing investigations, technology transfers, process validation programs, and cross-functional decision-making to drive compliance, operational excellence, and business objectives.
• Hands-on, visible leader with a strong player-coach mindset. Actively engages with manufacturing operations through routine Gemba presence, team coaching, barrier removal, and rapid resolution of operational, technical, and quality challenges.
• Experience scaling an internal commercial manufacturing organization.
• Experience with MES, ERP, LIMS, statistical process monitoring, Lean Six Sigma, and S&OP.

In this role you will:

Leadership & Organizational Development

• Lead, develop, and mentor a high-performing GMP Operations organization, fostering a culture of accountability, collaboration, and continuous improvement.
• Translate corporate and Technical Operations objectives into integrated operating plans, resource strategies, and measurable performance goals.
• Build organizational capabilities, develop future leaders, and drive employee engagement across the function.
• Partner cross-functionally to align priorities, manage risks, and ensure execution against business objectives.

GMP Manufacturing & Commercial Operations

• Provide strategic oversight of GMP manufacturing operations, ensuring operational readiness across facilities, personnel, equipment, materials, systems, and processes.
• Drive safe, compliant, and reliable manufacturing performance through operational excellence, right-first-time execution, and continuous improvement initiatives.
• Lead commercial manufacturing readiness, product launch activities, capacity planning, and transition to routine commercial supply.
• Partner with Supply Chain, Quality, Commercial, Clinical Operations, and Patient Operations to establish scalable end-to-end manufacturing and supply processes.

Technical & Process Excellence

• Oversee process validation, lifecycle management, process monitoring, and control strategies to ensure a state of continued compliance and operational performance.
• Lead technology transfer, MSAT activities, technical investigations, process improvements, and post-approval changes.
• Drive digital manufacturing initiatives, including MES/eBR, automation, manufacturing systems, and data-driven decision making.

Compliance

• Ensure alignment between manufacturing operations, regulatory commitments, and GMP requirements.
• Lead inspection readiness activities and support regulatory inspections, audits, and health authority interactions.
• Partner closely with Quality and Regulatory Affairs to proactively manage com