Senior Director, Global HEOR, Hemoglobinopathies

Vertex Pharmaceuticals LLC; Boston, Northern (MA, KY); Hybrid; USD 238,000 - 358,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Comprehensive benefits

Job summary

Vertex Pharmaceuticals LLC in Boston seeks a Senior Director of Global Health Economics & Outcomes Research (HEOR) to lead strategies and execution that optimize value for Hemoglobinopathies assets across development, launch and post-launch. You will oversee global HEOR studies, models and dissemination with a strong emphasis on payer engagement and market access.

You will partner with cross‑functional teams to integrate HEOR evidence into HTA submissions, manage staff, and advance global HEOR

Qualifications

• Advanced degree (PhD/MD/MPH/PharmD) in a relevant discipline.
• Proven track record in HEOR with publications in peer‑reviewed journals.
• Experience leading global HEOR strategies and cross‑regional teams.
• Experience with payer submissions and health technology assessments (HTAs).

Responsibilities

• Lead the HEOR Heme Disease Area strategy and execution from development through lifecycle.
• Oversee design and execution of HEOR studies and models; ensure high quality dissemination.
• Collaborate with global commercial, medical, and other functions to support access.
• Manage HEOR staff and cross‑functional disease strategy teams.
• Integrate HEOR evidence into submissions and payer communications for assets.

Skills

HEOR leadership

Health economics modeling

Observational research

Patient reported outcomes

Global HEOR plan development

Payer submissions

Communication skills

Regulatory/ethics knowledge

Team management

Education

PhD / MD / MPH / PharmD

Advanced degree in relevant discipline

Tools

Health economic modeling tools

Job description

Vertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes Research (HEOR) group in Boston, MA. The Health Economics & Outcomes Research Senior Director will lead strategies and execution of evidence generation that optimize the value proposition of Vertex’s inline and pipeline assets for the Hemoglobinopathies (Heme) Disease Area through each stage of development, including launch and post-launch phases. This position reports to Global HEOR Cell and Gene Therapy Lead. **Key Responsibilities:**· Serves as the HEOR Heme Disease Area Lead· Develops the HEOR strategy for assets in the Heme Disease Area from early development through product lifecycle· Serves as HEOR lead to cross-functional and cross-regional teams to align strategic plans to stakeholder needs and represent the voice of HEOR and, at times, market access· Ensures HEOR strategic plans are based on comprehensive review of internal and external stakeholder needs and appropriately aligned with clinical, medical and market access plans· Oversees execution of HEOR core deliverables including evidence generation plans, outcomes research studies, models (cost-effective analysis and budget impact models), GVDs, etc., and leads execution of deliverables for Casgevy· Supports the integration of HEOR evidence in health technology appraisal submissions for relevant assets· Serves as HEOR lead to cross-functional teams up through Disease Strategy Team· Collaborates closely with global commercial strategy, medical, clinical, and other functional teams to support and enhance access to marketed products across various regions· Oversees the design and execution of HEOR studies and applies best practices for HEOR analyses, modeling and dissemination; ensures the highest quality standards for research and dissemination· Responsibility for managing HEOR staff covering heme assets. **Knowledge and Skills:**· Extensive track record of publications in peer-reviewed journals demonstrating experience in patient reported outcomes, observational research, and health economic modeling· Demonstrated capabilities to develop global strategic HEOR plans and execute studies · Market Access experience, including direct experience in making submissions to relevant payers and interacting with them is strongly desired (US and EX-US)· Comprehensive understanding of clinical development strategies and trial designs· Strong communication skills, both verbal and written, including presentation skills to negotiate internally/externally often at higher levels· Strong technical aptitude· Broad and comprehensive understanding of the legal and regulatory environment of the pharmaceutical industry, demonstrated integrity on work-related compliance considerations and solid ethics · Ability to manage complexity and ambiguity in a highly matrixed work environment **Education and Experience:**· Advanced degree (PhD, MD, Master's degree, MPH, or PharmD) in a relevant discipline.· Typically requires 12 years of experience in health economics and outcomes research, or directly-related field and industry and 5 years of supervisory/management experience, or the equivalent combination of education and experience At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.**Pay Range:**$238,400 - $357,600**Disclosure Statement:**The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.**Flex Designation:**Hybrid-Eligible Or On-Site Eligible**Flex Eligibility Status:**In this Hybrid-Eligible role, you can choose to be designated as: 1. **Hybrid**: work remotely up to two days per week; **or select** 2. **On-Site**: work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.