Senior Director, Global HEOR, Hemoglobinopathies

Vertex Pharmaceuticals Incorporated; Boston (MA); Hybrid; USD 238,000 - 358,000; Full time

Job summary

Vertex is seeking a Senior Director of Global HEOR in Boston to lead evidence generation for Hemoglobinopathies. You will shape strategy, manage studies and models, and collaborate with commercial, medical, and regional teams to optimize access and value across development stages.

The role emphasizes leadership, governance, and high-quality HEOR outputs, contributing to launch and post-launch success with a focus on payer engagement.

Qualifications

• Extensive publications in peer-reviewed journals on PROs, observational research, and health economic modeling.
• Ability to develop global HEOR strategies and execute studies.
• Market access experience including payer submissions and regional interactions (US/EX-US).
• Understanding of clinical development strategies and trial designs.
• Strong communication skills for executive-level negotiation and presentations.
• Comprehensive regulatory and ethics understanding in pharma.
• Ability to navigate a complex, matrixed organization.

Responsibilities

• Lead HEOR strategy for the Heme Disease Area from development through lifecycle.
• Oversee HEOR studies, evidence generation plans, and budget impact models.
• Collaborate with cross-functional and cross-regional teams for alignment with stakeholders.
• Guide HEOR staff and ensure high-quality research and dissemination.
• Support integration of HEOR evidence in health technology appraisals and submissions.

Skills

HEOR leadership

Global strategy development

Market access

Clinical development strategies

Communication skills

Regulatory/compliance knowledge

Data modeling

Education

Advanced degree (PhD, MD, MPH, PharmD)

Job description

Job Description

Vertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes Research (HEOR) group in Boston, MA. The Health Economics & Outcomes Research Senior Director will lead strategies and execution of evidence generation that optimize the value proposition of Vertex's inline and pipeline assets for the Hemoglobinopathies (Heme) Disease Area through each stage of development, including launch and post-launch phases. This position reports to Global HEOR Cell and Gene Therapy Lead.

Key Responsibilities:

• Serves as the HEOR Heme Disease Area Lead
• Develops the HEOR strategy for assets in the Heme Disease Area from early development through product lifecycle
• Serves as HEOR lead to cross-functional and cross-regional teams to align strategic plans to stakeholder needs and represent the voice of HEOR and, at times, market access
• Ensures HEOR strategic plans are based on comprehensive review of internal and external stakeholder needs and appropriately aligned with clinical, medical and market access plans
• Oversees execution of HEOR core deliverables including evidence generation plans, outcomes research studies, models (cost-effective analysis and budget impact models), GVDs, etc., and leads execution of deliverables for Casgevy
• Supports the integration of HEOR evidence in health technology appraisal submissions for relevant assets
• Serves as HEOR lead to cross-functional teams up through Disease Strategy Team
• Collaborates closely with global commercial strategy, medical, clinical, and other functional teams to support and enhance access to marketed products across various regions
• Oversees the design and execution of HEOR studies and applies best practices for HEOR analyses, modeling and dissemination; ensures the highest quality standards for research and dissemination
• Responsibility for managing HEOR staff covering heme assets.

Knowledge and Skills:

• Extensive track record of publications in peer-reviewed journals demonstrating experience in patient reported outcomes, observational research, and health economic modeling
• Demonstrated capabilities to develop global strategic HEOR plans and execute studies
• Market Access experience, including direct experience in making submissions to relevant payers and interacting with them is strongly desired (US and EX-US)
• Comprehensive understanding of clinical development strategies and trial designs
• Strong communication skills, both verbal and written, including presentation skills to negotiate internally/externally often at higher levels
• Strong technical aptitude
• Broad and comprehensive understanding of the legal and regulatory environment of the pharmaceutical industry, demonstrated integrity on work-related compliance considerations and solid ethics
• Ability to manage complexity and ambiguity in a highly matrixed work environment

Education and Experience:

• Advanced degree (PhD, MD, Master's degree, MPH, or PharmD) in a relevant discipline.
• Typically requires 12 years of experience in health economics and outcomes research, or directly-related field and industry and 5 years of supervisory/management experience, or the equivalent combination of education and experience

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$238,400 - $357,600

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]