Senior Director, Global Digital & Technology Systems Engineering

BeiGene; United States; Remote; USD 208,000 - 278,000; Full time

Benefits offered by this job

Medical benefits

Dental benefits

Vision benefits

401(k) plan

Life Insurance

Paid Time Off

Wellness programs

Job summary

BeOne is seeking a Senior Director of Global Digital & Technology Systems Engineering to lead end-to-end systems engineering for externally developed platforms and data pipelines in a global biotech setting. You will shape HPC, containerized environments, and AI architectures while aligning R&D needs with enterprise IT standards.

The role requires deep pharma/biotech domain knowledge, strong leadership, and expertise in ML/GenAI patterns, observability, and secure data handling.

Qualifications

• 12+ years of professional experience in data, digital & information technology with direct oversight and experience in the Systems Engineering area in the Pharmaceutical, Biotechnology, and/or Medical Device industries
• 7+ years of proven leadership experience at a senior level, directing a team of multi-skilled direct reports and associate-level team members
• Strong experience in ML/AI/genAI methods and technologies from a Systems Engineering angle
• Business relationship management acumen and demonstrable success as a change agent leading or contributing to significant transformational initiatives in organizations
• Strong experience with software lifecycle methodologies, 21CFR Part 11 compliance, and GxP computer systems validation (CSV), ICH guidelines
• Accomplished in building and development of people and teams, comfortable working with a broad cross section of people in direct and matrixed relationships
• Proficient in various project management disciplines (i.e., Agile, Scrum, Kanban, Lean etc.)
• Bachelor or above

Responsibilities

• Lead, mentor, and manage a high-performing GRDTS team dedicated to Systems Engineering
• Oversee engineering and deployment strategies for platforms and systems across on-prem, hybrid cloud, and SaaS environments
• Architect robust API layers and data buses to ensure data interoperability across the pipeline
• Implement observability, distributed tracing, and real-time telemetry for platform health and performance
• Manage HPC clusters and containerized environments for compute-heavy processing
• Govern data lakes and pipelines governing research data lifecycle
• Oversee software lifecycle, patch management, and automated deployments for long-term sustainability
• Design and implement Retrieval-Augmented Generation (RAG) architectures and multi-agent AI patterns
• Drive change strategy for infrastructure overhauls and cloud migrations
• Collaborate with Global IT to enforce secure AI proxies and gateways
• Engage with stakeholders to sponsor continuous improvements
• Lead governance and risk mitigation in enterprise IT security and IP stewardship
• Deliver scalable AI/ML architecture patterns and blueprints
• Ensure alignment of R&D systems with enterprise standards

Skills

Team leadership

Strategic planning

AI / GenAI

Systems engineering

Cloud & data architecture

Stakeholder management

Pharma domain knowledge

Change management

Education

Bachelor or above

Tools

High-Performance Computing

Containerization

Job description

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

BeOne is a global biopharmaceutical company dedicated to the discovery and development of innovative drug therapies for the treatment of cancer. At BeOne we believe that access to life-changing medicine sees no borders.

General Description:

The Senior Director, Global Digital & Technology Systems Engineering operates primarily as the primary point of contact and strategic bridge to the Global Technology Solutions (Enterprise IT function), ensuring all business-specific systems align with Enterprise infrastructure, security, identity management, and cloud platform standards.

The role owns the end-to-end remit for systems engineering for externally developed platforms & solutions, integration engineering, and technical application lifecycles across the organization. This includes designing, configuring, and deploying high-performance computing (HPC) clusters and containerized environments, alongside implementing modern system observability frameworks and robust data pipeline integration architectures. Additionally, this leader acts as a deep technical subject matter expert who advises on and engineers foundational AI architecture and systems engineering patterns, including advanced RAG pipelines, agentic AI frameworks & multi-modal integration patterns.

As a member of the GRDTS Leadership Team, the Senior Director is an active contributor to developing and executing BeOne’s R&D systems engineering strategy, defining necessary technology investments, and driving transparency in prioritization and planning. The Senior Director and their team are responsible for ensuring the strategy is fully aligned with business needs, positioning GRDTS to deliver and realize compelling business value.

A successful candidate is a dynamic leader who brings deep end-to-end pharma / biotech domain knowledge with technical expertise related to digital & technology systems, systems engineering, processes, data science, analytics, AI, & genAI. Ability to manage multiple projects across different sub-functions in a global, geographically diverse environment, and building and sustaining teams in times of ambiguity are all critical success factors for this role. An ideal candidate will adapt communication cadences and problem-solving skills to accommodate stakeholders, partners, and team members, exercise diplomacy and effective influence to reach consensus, and build strong relationships.

Essential Functions of the job:

Enterprise IT Alignment & Collaboration

• Serve as the single point of contact and strategic bridge to Global Technology Solutions (Enterprise IT function), ensuring R&D systems align with global infrastructure, corporate cybersecurity, identity management, and cloud platform standards while advocating for specialized technical requirements.

Platforms & Systems Engineering

• Oversee the engineering, architecting, and deployment strategies for platforms & systems, balancing on-prem, hybrid cloud, and multi-tenant SaaS environments based on business needs.

• Architect robust, low-latency API layers and data buses to bridge disparate third-party applications, ensuring seamless data interoperability across the end-to-end organizational pipeline.

• Implement modern observability frameworks, distributed tracing, and real-time telemetry across infrastructure and applications to proactively manage system health, identify bottlenecks, and resolve failures.

• Lead the design, configuration, and deployment of High-Performance Computing (HPC) clusters and containerized environments optimized for compute-heavy, complex processing systems.

• Provide oversight for the engineering and maintenance of the underlying storage fabric, data lakes, and pipelines that manage the full ingest, storage, and processing lifecycle of datasets for the Research function.

• Manage the systems engineering and product development lifecycle, codebase evolution, patch management, and automated deployments of customized platforms and applications, ensuring long-term technical sustainability for the Research function.

Foundational AI Architectures & Workflow Patterns

• Act as the technical SME & oversee the design, on Retrieval-Augmented Generation (RAG) architecture, engineering vector storage integrations, advanced chunking strategies, and semantic retrieval layers.

• Design and implement agentic AI system patterns, orchestrating multi-agent frameworks that can securely handle complex, multi-step autonomous workflows and tasks.

• Engineer pipelines capable of handling multi-modal AI inputs and outputs, allowing core systems to ingest, process, and reason across diverse data types simultaneously.

Change Management & Digital Adoption

• Manage the technical change strategy for foundational infrastructure overhauls and cloud migrations in collaboration with GTS.

• Drive organizational alignment around unified integration standards, guiding systems engineering, development, and vendor teams toward optimized technical architectures.

Governance & Risk Mitigation

• Collaborate with Global Technology Solutions (Enterprise IT) in the technical implementation of secure, enterprise-grade AI proxy layers and gateways, ensuring that proprietary data, information & systems, and intellectual property are strictly sandboxed.

GRDTS Leadership:

• Team Leadership & Talent Development:

• Operational Excellence, Compliance & Governance:

• Collaboration & Partnership:

• Engage with peers to define, sponsor, and execute continuous improvements.

Supervisory Responsibilities:

• Lead, mentor, and manage a high-performing GRDTS team dedicated to Systems Engineering.

Key Capabilities :

• Enterprise-to-R&D Infrastructure Bridging: Acting as the primary liaison to global Enterprise IT, aligning R&D platforms with Enterprise cybersecurity, identity management, and cloud standards while successfully advocating for specialized Research needs.

• External Platform Technical Assessment: Technically evaluating and stress-testing externally developed platforms, vendor solutions, and SaaS architectures to verify their scalability, security, integration readiness, and alignment with Enterprise engineering standards.

• Internal & Vendor Platform Integration: Engineering secure, unified integration layers that connect internal applications seamlessly with externally developed third‑party platforms.

• Full-Ecosystem Observability & Reliability: Implementing real‑time telemetry and monitoring across all internal and vendor‑hosted applications to maximize platform uptime and performance.
• Advanced Computer & AI Architecture Scaling: Scalability planning for cloud environments, high-performance computing, and emerging AI frameworks (e.g., enterprise RAG, secure AI gateways).
• Technical Governance & Talent Upskilling: Driving adherence to unified architectural standards across internal teams and vendors while managing the reskilling roadmap for technical staff.

Key Competencies :

• Objective Technical Due‑Diligence: A highly analytical approach to reviewing vendor codebases, architecture diagrams, APIs, and SLAs to separate marketing claims from true engineering readiness.
• Enterprise & Domain Diplomatic Mindset: The ability to navigate global Enterprise IT processes, translate core infrastructure constraints to the R&D team, and effectively negotiate exceptions for specialized scientific technical stacks.
• Ecosystem‑Level System Thinking: Viewing internal applications, cloud infrastructure, and external vendor platforms as a singular, cohesive, and scalable system.
• Enterprise Risk & IP Stewardship: A security‑first mindset committed to protecting Enterprise data and intellectual property across all internal and vendor‑hosted environments.
• Transformational Change Leadership: The ability to coach, upskill staff, and drive unified technical standards across groups.
• Resilient Crisis Management: Providing decisive technical leadership during major platform upgrades, infrastructure overhauls, or critical system outages.

Key Deliverables :

• R&D Systems Blueprint: Technical reference documentation detailing R&D systems and external vendor platforms.
• Vendor Technical Assessment & Feasibility Reports: Formal architectural scorecards and technical risk assessments reviewing the scalability, code health, integration viability, and security posture of proposed third‑party software.
• Scalable AI/ML Architecture Patterns & Blueprints: Reusable infrastructure configurations, standardized RAG pipeline templates, and multi‑agent workflow frameworks engineered to rapidly accelerate and scale projects.
• Ecosystem Observability & Telemetry Views: A centralized, live monitoring infrastructure providing end‑to‑end health tracking and alert routing across all external systems and platforms.
• Cross‑Functional Governance & Technical Alignment Agreements: Formally negotiated architecture and compliance agreements co‑authored with global Enterprise IT to approve R&D systems.

Other Qualifications:

• 12+ years of professional experience in data, digital & information technology with direct oversight and experience in the Systems Engineering area in the Pharmaceutical, Biotechnology, and/or Medical Device industries
• 7+ years of proven leadership experience at a senior level, directing a team of multi‑skilled direct reports and associate‑level team members.
• Strong experience in ML/AI/genAI methods and technologies from a Systems Engineering angle.
• Business relationship management acumen and demonstrable success as a change agent leading or contributing to significant transformational initiatives in organizations.
• Strong experience with software lifecycle methodologies, 21CFR Part 11 compliance, and GxP computer systems validation (CSV), ICH guidelines.
• Accomplished in building and development of people and teams, comfortable working with a broad cross section of people in direct and matrixed relationships
• Proficient in various project management disciplines (i.e., Agile, Scrum, Kanban, Lean etc.)

Education Required:

• Bachelor or above

Travel:

• Some travel expected as part of assigned duties

BeOne Global Competencies:

When we exhibit our values of Patients First, Collaborative Spirit, Bold Ingenuity and Driving Excellence, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self‑Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results‑Oriented

Global Competencies

When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self‑Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results‑Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Salary Range: $207,800.00 - $277,800.00 annually

BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non‑Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.

We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact [e-mail].