Senior Director, Commercialization Technology Architect

Vertex Pharmaceuticals Inc (US); Boston (MA); Hybrid; USD 228,000 - 342,000; Full time

Benefits offered by this job

Medical, dental and vision benefits

Paid time off including a week-longamp

Educational assistance and studentloan

Commuting subsidy

Matching charitable donations

401(k) and more

Job summary

Vertex Pharmaceuticals seeks a Senior Enterprise Architect to lead architecture across Commercial and Medical ecosystems, defining reference architectures, patterns, and governance. You will align architecture with enterprise strategies and guide cross-functional teams.

Responsibilities include designing data and integration architectures, ensuring SOX/GxP compliance, and partnering with Product Management, Engineering, and Data teams to deliver scalable, production-ready solutions.

Qualifications

• Deep expertise in enterprise architecture, solution design, and distributed systems.
• Experience with CRM and commercial platforms (Salesforce, Veeva).
• Proven ability to design complex integrations and data architectures at scale.
• Hands-on with cloud and data warehouse platforms (AWS, Azure, Snowflake, Databricks).
• Experience designing AI/ML and LLM-based capabilities; security and compliance knowledge.

Responsibilities

• Define and maintain target-state architecture across Commercial and Medical ecosystems.
• Own integration patterns across Salesforce, Veeva, data platforms, and downstream systems.
• Partner with engineering to define standards across cloud and data platforms; governance.
• Ensure architectures meet SOX, GxP, privacy, and security requirements.
• Translate product requirements into executable architectures and provide guidance.

Skills

Enterprise architecture

CRM experience

Data architecture

Cloud platforms

AI/ML systems

Security/compliance

Engineering guidance

Education

Bachelor's or Master's degree in Computer Science, Engineering, or related field

Job description

Key Responsibilities

• Architecture Strategy & Standards
  Define and maintain target-state architecture across Commercial and Medical ecosystems
  Establish reference architectures, design patterns, and engineering standards for AI-enabled systems
  Govern architecture alignment across CRM, omnichannel, patient services, and enterprise platforms
  Ensure consistency with enterprise architecture and platform strategies
• Integration & Data Architecture
  Own integration patterns and data flows across Salesforce, Veeva, data platforms, and downstream systems
  Define real-time and batch data architectures, including event-driven patterns and APIs
  Ensure alignment with enterprise data platforms (e.g., MDM, Snowflake, Databricks)
  Partner with Data teams to ensure data readiness, lineage, and interoperability
• Technology & Platform Governance
  Partners with engineering function and core technology to define standards across cloud and data platforms MDM, Snowflake, Databricks, Snowflake supporting Commercial and Medical affairs domains
  Lead architecture decisions for build vs. buy vs. partner solutions
  Establish environment, deployment, and DevOps architecture patterns within the Commercial and Medical affairs domains
  Maintain architecture documentation for scalability, reuse, and audibility
• Security, Risk & Compliance
  Ensure architectures meet SOX, GxP, privacy, and security requirements
  Define patterns for observability, audibility, and controls in AI systems
  Partner with InfoSec, Legal, Privacy, and Quality to embed compliance by design
• Delivery Enablement
  Partner with Product Management, Engineering, and Data teams to translate product requirements into executable architectures
  Provide hands-on guidance to ensure solutions are production-ready and aligned to standards
  Serve as final architecture authority for design reviews and major platform decisions

Knowledge & Skills

• Deep expertise in enterprise architecture, solution design, and distributed systems
• Strong experience with CRM and commercial platforms (Salesforce, Veeva)
• Proven ability to design complex integrations and data architectures at scale
• Hands-on experience with cloud and data warehouse platforms (AWS, Azure, Snowflake, etc...) and modern data stacks
• Experience designing systems incorporating AI/ML and LLM-based capabilities
• Strong understanding of AI architectures (e.g. MCP)
• Expertise in security, compliance, and regulated environments (SOX, GxP)
• Ability to translate complex architecture into clear guidance for engineering teams

Education & Experience

Bachelor's or Master's degree in Computer Science, Engineering, or related field

12+ years of experience in enterprise architecture or solution architecture roles

Experience in pharma, biotech, or regulated healthcare environments strongly preferred

Proven track record delivering enterprise-scale platform and integration architecture

Experience working across Commercial, Medical, or patient services systems

Pay Range

Pay Range: $228,000 - $342,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

Benefits

• From medical, dental and vision benefits
• Generous paid time off (including a week-long company shutdown in the Summer and the Winter)
• Educational assistance programs including student loan repayment
• A generous commuting subsidy
• Matching charitable donations
• 401(k) and so much more

Flex Designation

Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail].

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life‑shortening genetic diseases - cystic fibrosis, sickle cell disease and transfusion‑dependent beta thalassemia - and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency.

Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East.

Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune's 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram.

The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.