Senior Director, Clinical Pharmacology

BridgeBio Pharma; Owens (OH); Hybrid; USD 265,000 - 289,000; Full time

Benefits offered by this job

Market-leading compensation

401(k) with employer match

Employee Stock Purchase Program (ESPP)

Hybrid work model

Company-paid holidays

Job summary

BridgeBio Pharma in the United States seeks a Senior Director, Clinical Pharmacology to lead clinical pharmacology and pharmacometrics strategies across diverse drug development programs, with oversight of population PK, exposure‑response, PK/PD, and PBPK models. This hybrid role involves managing external bioanalytical CROs, contributing to regulatory submissions, and communicating findings to internal and external stakeholders; requires a Ph.D.

or Pharm.D.

Qualifications

• Ph.D. or Pharm.D. in Clinical Pharmacology, Pharmaceutical Sciences, or a related discipline.
• 10+ years of relevant experience in biotech or pharmaceutical industry.
• Demonstrated track record in population PK, PK/PD, PBPK, and quantitative data analysis.

Responsibilities

• Develop and implement clinical pharmacology and pharmacometrics strategies across all stages of clinical development.
• Oversee design and application of PK/PD, population PK, and PBPK models to inform decision‑making.
• Manage external bioanalytical CROs and contribute to regulatory documents and interactions with health authorities.
• Design and oversee PK studies, protocols, and analysis plans; author reports as needed.
• Present results to internal and external stakeholders and contribute to publications and conferences.

Skills

Population PK

PK/PD

PBPK modeling

Quantitative data analysis

Regulatory strategy

Education

Ph.D. or Pharm.D. in Clinical Pharmacology

Job description

Mavericks Wanted

When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement…read on

In 2015, we pioneered a "moneyball for biotech" approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible.

Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we’ll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation-including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work.

What You’ll Do

Senior Director, Clinical Pharmacology, leading clinical pharmacology and pharmacometrics strategies on cross‑functional teams. This role will have oversight over the design and application of population PK, exposure‑response, PK/PD, and PBPK models at various stages of the clinical drug development programs for predominantly small molecules. This role will also have oversight over external bioanalytical CROs. The position will also support regulatory strategy by authoring key clinical pharmacology documents and contributing to interactions with global health authorities, while effectively communicating findings to internal and external stakeholders.

Responsibilities

• Develop and implement clinical pharmacology and pharmacometrics strategies across all stages of clinical development including pediatric development programs.
• Manage the design, development, and application of NCA, population PK, exposure‑response, PK/PD, and PBPK models to inform decision‑making across programs.
• Oversee modeling and simulation‑based analyses to support dose selection and study design for clinical trials in pediatric populations, and support global regulatory submissions and labeling.
• Author and contribute to clinical pharmacology sections of regulatory documents (e.g., IB, DSUR, briefing books, NDA/MAA submissions) and support interactions with global regulatory agencies.
• Design clinical pharmacology studies and manage study execution and CROs/vendors. Conduct PK data analyses, provide study‑level oversight, including authoring, review, and approval of protocols, analysis plans, and reports.
• Present results to internal teams and external stakeholders, including contributions to scientific publications, abstracts, and conference presentations.

Where You’ll Work

This is a hybrid role and requires in‑office collaboration 2‑3x per week in our San Francisco Office.

Who You Are

Ph.D. or Pharm.D. in Clinical Pharmacology, Pharmaceutical Sciences, or a related discipline, with 10+ years of relevant experience in the biotechnology or pharmaceutical industry.

Demonstrated track record in population PK, PK/PD, mechanistic modeling (e.g., PBPK), and quantitative data analysis, with a proven ability to apply these approaches to inform clinical development and regulatory strategy; experience in pediatric drug development is preferred.

Strong understanding of global regulatory guidances related to clinical pharmacology, model‑informed drug development, bioanalytical method validation, and GLP/GxP regulations.

Excellent analytical, critical thinking, and problem‑solving skills, with the ability to translate complex quantitative findings into clear, actionable insights.

Strong written, verbal, and interpersonal communication skills, with experience presenting to internal teams and external stakeholders.

Salary

$265,000-$289,000 USD

As a global company, our comprehensive benefits may vary based on location. We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return.

For BridgeBio Full‑Time U.S Based Roles:

Financial & Rewards

• Market‑leading compensation
• 401(k) with employer match
• Employee Stock Purchase Program (ESPP)
• Pre‑tax commuter benefits (transit and parking)
• Referral bonus for hired candidates
• Subsidized lunch and parking on in‑office days

Health & Well‑Being

• 100% employer‑paid medical, dental, and vision premiums for you and your dependents
• Health Savings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA)
• Fertility & family‑forming benefits
• Expanded mental health support (therapy and coaching resources)
• Hybrid work model with flexibility
• Flexible, "take‑what‑you‑need" paid time off and company‑paid holidays
• Comprehensive paid medical and parental leave to care for yourself and your family

Skill Development & Career Paths:

• People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility
• We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching
• We celebrate strong performance with financial rewards, peer‑to‑peer recognition, and growth opportunities