Senior Director, Bioinformatics

Nautilus Biotechnology; San Carlos (CA); On-site; USD 224,000 - 337,000; Full time

Job summary

Nautilus Biotechnology in San Carlos, CA is seeking a Sr. Director of Bioinformatics to lead multiple bioinformatics teams and partner with R&D, engineering and product groups.

The role requires in-office presence at least three days per week and a track record of guiding complex projects in biotech. You will shape experimental strategy, deliver analyses for both R&D and customer-facing products, and drive cross-functional collaboration while maintaining high standards of scientific leadership

Qualifications

• 15+ years in a high performing biotechnology organization.
• 10+ years in a leadership role.
• PhD in Bioinformatics or related field.
• Proven track record leading bioinformatics teams on complex projects.
• Experience partnering with scientists developing novel approaches.

Responsibilities

• Lead, manage, mentor, and grow several bioinformatics teams across experience levels.
• Partner with experimental, engineering, and product teams to guide next steps.
• Collaborate with commercial and software teams to translate capabilities into solutions.
• Shape experimental strategy and priorities; design of experiments.
• Ensure successful delivery of data analyses and processing solutions in R&D and product contexts.
• Operate effectively in fast-moving, ambiguous environments; balance risk and priorities.
• Provide hands-on technical contributions as appropriate.
• As a leadership team member, drive corporate strategy and be a Nautilus ambassador.

Skills

Leadership

Biotech

Bioinformatics

Data analysis

Programming

Education

PhD in Bioinformatics or related

Job description

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world‑class team of builders, innovators, and dreamers across a wide range of disciplines.

We are looking for a Sr. Director of Bioinformatics to join our growing company. Being successful in our goal of delivering novel proteomic insights to the world hinges on our ability to analyze and understand large, complex, and diverse data sets that result from our experimental efforts, surfacing any key insights that might be hidden within. A candidate stepping into this highly visible role will provide both technical and people leadership for diverse bioinformatics teams and work with R&D leaders to define strategic direction. Our novel proteomic technology is in its formative stages, which means that anyone in this role will have an outsized impact on our technology and customer success.

This position will report to the SVP of Product Development and is located in San Carlos, CA. A minimum of three days per week in office is required.

Responsibilities

• You will lead, manage, mentor, and grow several teams of bioinformaticians across a wide range of experience levels, areas of expertise, and scopes of responsibility
• You will be a true thought partner to the experimental, engineering, and product teams working alongside them to guide next steps, prioritize tradeoffs, and accelerate learning
• You will work with the commercial and software teams to translate bioinformatics capabilities into scalable, reliable customer solutions.
• You will guide the design of individual experiments as well as shape broader experimental strategy and priorities.
• You will be responsible for the successful delivery of data analyses and processing solutions in both R&D and customer‑facing product context
• You will operate effectively in fast‑moving, ambiguous environments, balancing risk, setting priorities, and helping teams navigate uncertainty
• You will provide hands‑on technical contributions as appropriate to your teams’ strengths and gaps
• As a member of our leadership team, you will be expected to drive corporate strategy & initiatives, be a positive cultural role model, and be one of Nautilus’s ambassadors to the world!

Requirements

• You have 15+ years of relevant experience in a high performing biotechnology organization, including 10+ years of experience in a leadership role
• You have a PhD in Bioinformatics or a related field
• You have a proven track record of leading many bioinformatics teams to success on very complex projects that bring together a wide variety of disciplines and skill sets
• You have demonstrated experience partnering with scientists developing novel biochemical approaches or assays.
• You know how to create and nurture highly performing bioinformatics teams through a combination of coaching, hiring, performance reviews, technical mentorship, and other management techniques
• You are fluent in a wide variety of statistical analysis skills, data processing and visualization approaches, programming languages and environments, biological experimental techniques, and the ability to quickly acquire expertise in new topics on the fly.
• You are a creative thinker capable of developing new foundational approaches for extracting value from entirely novel data sets and generating actionable conclusions from imperfect data (e.g. missing values, batch effects, highly-skewed distributions, outliers, etc.)
• You have strong organization, communication, problem solving, and project management skills, and a willingness to jump in to help wherever it is needed
• You are a leader who is trusted by everyone within the organization and can lead directly as well as through collaboration & influence
• You have fun when building complex systems that solve large, novel problems while working side‑by‑side with experts from a variety of disciplines
• Travel required up to 20% of the time

Compensation Range: $224K - $337K