Senior Development Program Lead, Rare Disease

Alnylam Pharmaceuticals, Inc.; United States; Hybrid; USD 210,000 - 310,000; Full time

Job summary

Alnylam Pharmaceuticals in the United States is seeking a Program Lead, Development for rare diseases to provide strategic and operational leadership of two early-stage programs. You will drive integrated development strategies, establish milestones, and guide cross-functional teams to execute critical early clinical programs.

The role requires seasoned drug development leadership, ability to navigate ambiguity, and engagement across Research, Clinical Operations, Regulatory Affairs,

Qualifications

• Advanced degree in medicine, science, pharmacy, or related discipline.
• 10+ years in biotech/pharma drug development with cross-functional leadership.
• Rare disease drug development experience preferred.

Responsibilities

• Lead integrated, cross-functional strategies for early-stage rare disease programs.
• Establish program vision, milestones, and align scientific, regulatory, operational, and business considerations.
• Develop fit-for-purpose plans reflecting asset stage, evidence, investment, and future potential.
• Lead cross-functional teams on proof-of-concept strategies and data requirements.
• Integrate scientific evidence, clinical data, regulatory considerations, and patient needs into strategy.
• Translate complex information into clear recommendations and executable plans.
• Anticipate risks, establish mitigation plans, and escalate issues for timely decisions.
• Align resources and expertise with program milestones and deliverables.
• Foster an inclusive, high-performing team and transparent communication.
• Prepare and present strategy, status, risks, and scenarios to governance and senior leaders.
• Document decisions, dependencies, and risks across the organization.
• Champion programs and articulate scientific rationale, patient impact, and development path.

Skills

Cross-functional leadership

Drug development

Rare disease

Strategic planning

Program management

Leadership

Regulatory strategy

Clinical development

Education

MD/PhD/PharmD or equivalent

Job description

Alnylam Pharmaceuticals in the United States is seeking a Program Lead, Development for rare diseases to provide strategic and operational leadership of two early-stage programs. You will drive integrated development strategies, establish milestones, and guide cross-functional teams to execute critical early clinical programs.

The role requires seasoned drug development leadership, ability to navigate ambiguity, and engagement across Research, Clinical Operations, Regulatory Affairs,