Director, Clinical Research - RNAi Therapeutics Lead

Alnylam Pharmaceuticals, Inc.; Philadelphia (Philadelphia County); On-site; USD 255,000 - 345,000; Full time

Benefits offered by this job

Medical, dental & vision

Life and disability insurance

401(k) with company match

Paid time off & holidays

Wellness days & recharge breaks

Job summary

Alnylam Pharmaceuticals, Inc. is seeking an imaginative physician drug developer to provide clinical leadership across neurology and hematology.

The Director, Clinical Research will lead plasminogen program development from Phase 2 to Phase 3 and drive global regulatory interactions in a matrix organization. The role requires strategic direction, collaboration with Regulatory, Biostatistics, and Medical Affairs, and accountability for study timelines and deliverables; strong leadership and

Qualifications

• MD with strong research background or MDPhD with best clinical and/or research training as shown through research support and peer‑reviewed publications.
• Board Certification in hematology desirable.
• 3+ years industry experience or equivalent clinical academic research experience.
• Familiarity with biostatistics and regulatory agency practices.
• Ability to present ideas and document complex medical concepts clearly.
• Leadership and collaboration in a matrix environment.

Responsibilities

• Be a subject matter expert for the relevant disease area(s).
• Be the strategic leader providing a strong voice for the clinical program.
• Develop creative but realistic drug development approaches and lead clinical efforts toward global regulatory approvals.
• Oversee trial conduct and safety.
• Collaborate with Preclinical, Regulatory Affairs and Medical Affairs for integrated product development plans.
• Accountable for timelines and deliverables in Clinical Research and Operations.
• Supervise major regulatory submissions, articles, abstracts, and presentations.
• Review and sign off on protocols, investigator brochures and informed consent forms.

Skills

MD/MDPhD

Board Certification

Clinical research experience

Leadership in matrix teams

Education

MD/MDPhD

Job description

Alnylam Pharmaceuticals, Inc. is seeking an imaginative physician drug developer to provide clinical leadership across neurology and hematology.

The Director, Clinical Research will lead plasminogen program development from Phase 2 to Phase 3 and drive global regulatory interactions in a matrix organization. The role requires strategic direction, collaboration with Regulatory, Biostatistics, and Medical Affairs, and accountability for study timelines and deliverables; strong leadership and