Senior Computational Chemistry Scientist: Lead Drug Design

Revolution Medicines; San Francisco (CA); On-site; USD 170,000 - 212,000; Full time

Job summary

Revolution Medicines, headquartered in Redwood City, CA, is seeking an accomplished Senior Scientist II to lead computational chemistry efforts across drug discovery programs. You will shape computational strategy and drive design and optimization of novel therapeutics at the intersection of structural biology, medicinal chemistry, biology, and data science.

As a key contributor, you will guide hit finding, evaluate SAR with multi-omics data, and collaborate with chemistry and analytics teams to

Qualifications

• Ph.D. in computational chemistry or related field.
• 5+ years in biotech/pharma; proven drug discovery impact.
• Expert-level knowledge of docking, VS, MD, QM.
• Experience with cheminformatics, data science, ML software.
• Scientific programming in Bash, Python, R, Java, C.
• Excellent communication and cross-disciplinary collaboration.

Responsibilities

• Lead computational chemistry on discovery teams with strategy.
• Integrate SAR and structural data to guide design.
• Collaborate with medicinal chemistry; communicate rationale.
• Design and implement virtual screening workflows.
• Apply physics-based modeling and free energy methods.
• Partner with AI/ML teams for molecular design workflows.
• Drive hit-finding and diversify chemical libraries.

Skills

Docking

Virtual screening

MD simulation

QM calculations

Cheminformatics

Data science

Machine learning

Scripting

Education

PhD in computational chemistry

Tools

Bash

Python

R

Java

C

Job description

Revolution Medicines, headquartered in Redwood City, CA, is seeking an accomplished Senior Scientist II to lead computational chemistry efforts across drug discovery programs. You will shape computational strategy and drive design and optimization of novel therapeutics at the intersection of structural biology, medicinal chemistry, biology, and data science.

As a key contributor, you will guide hit finding, evaluate SAR with multi-omics data, and collaborate with chemistry and analytics teams to