Senior Clinical Trial Manager

Actalent; United States; Hybrid; USD 152,000 - 193,000; Full time

Benefits offered by this job

Hybrid work model

Job summary

Actalent is seeking a Sr. Clinical Trial Manager to provide operational leadership for oncology studies, overseeing study maintenance, CRO relationships, and data quality initiatives in a biotech environment.

The role requires 6+ years of clinical operations experience, sponsor-side oncology trial leadership, and strong cross-functional collaboration in a hybrid South San Francisco setting. 12-month contract with potential extension.

Qualifications

• Bachelor's degree in Life Sciences or related field.
• Minimum 6+ years of clinical operations experience in biotech/pharma.
• Direct sponsor-side oncology trial management experience.

Responsibilities

• Lead operational management and oversight of oncology trials from conduct to closeout.
• Drive maintenance activities including enrollment oversight and site management.
• Manage site closeouts across multiple sites.
• Provide oversight of CRO performance for timely, high-quality execution.
• Serve as liaison between internal teams, CROs, investigators, and labs.
• Oversee vendor relationships including central laboratories and patient support.
• Collaborate with Data Management and CRO teams on data cleaning and reporting.
• Support IITs, academic collaborations, and external research partnerships.
• Identify risks and communicate status and recommendations to stakeholders.
• Ensure compliance with ICH-GCP, FDA/EMA, and SOPs.

Skills

Clinical trial management

Sponsor-side oncology trials

CRO/vendor management

Study maintenance & closeout

ICH-GCP FDA EMA

Cross-functional collaboration

Data review & issue resolution

Education

Bachelor's degree in Life Sciences

Job description

Job Title: Sr. Clinical Trial Manager

Hybrid in South San Francisco, 1x/week

12-month initial contract with potential for extension and conversion

Job Description

We are seeking an experienced Sr. Clinical Trial Manager to provide operational leadership for ongoing oncology clinical studies and external research collaborations. This role will be responsible for study maintenance, vendor oversight, site closeout activities, data quality initiatives, and cross-functional coordination across internal and external stakeholders. The ideal candidate is a seasoned sponsor-side oncology clinical operations professional with a proven track record of independently leading studies, managing CROs and vendors, and driving execution through study maintenance and closeout in a biotech environment.

Key Responsibilities

• Lead operational management and oversight of oncology clinical studies from study conduct through closeout.
• Drive study maintenance activities, including enrollment oversight, site management, study metrics tracking, data review, and operational issue resolution.
• Manage large-scale site closeout activities across multiple clinical sites.
• Provide strategic oversight and performance management of CRO partners to ensure timely, high-quality study execution.
• Serve as the primary operational liaison between internal teams, CROs, investigators, laboratories, and external vendors.
• Oversee multiple vendor relationships, including CROs, central/specialty laboratories, and patient support or concierge service providers.
• Collaborate with Data Management and CRO teams to support data cleaning, query resolution, study reporting, and database readiness.
• Support operational execution of investigator-initiated trials (IITs), academic collaborations, and future clinical research partnerships.
• Identify risks, develop mitigation strategies, and proactively communicate study status, challenges, and recommendations to cross-functional stakeholders.
• Ensure compliance with ICH-GCP guidelines, applicable regulatory requirements, and company SOPs.

Essential Skills

• Bachelor's degree in Life Sciences or a related scientific discipline.
• Minimum 6+ years of clinical operations experience within a biotechnology or pharmaceutical company.
• Direct sponsor-side early phase oncology clinical trial management experience.
• Demonstrated experience serving as the operational lead or study owner for oncology clinical trials (Sr. CTM or comparable level).
• Strong experience managing CROs from the sponsor perspective, including performance oversight, escalation management, and accountability.
• Experience managing studies during study conduct, maintenance, data cleaning, and closeout phases.
• Strong experience overseeing global early phase studies and multiple vendor relationships.
• Strong understanding of ICH-GCP, FDA, EMA, and international clinical trial regulations.
• Excellent communication skills with a demonstrated ability to provide transparent operational updates, appropriately elevate risks, and effectively disseminate information across cross-functional teams.
• Ability to work independently and effectively within a cross-functional team environment.

Additional Skills & Qualifications

• Solid tumor oncology experience strongly preferred.
• Experience supporting investigator-initiated trials (IITs), clinical collaborations, or externally sponsored research strongly preferred.
• Experience managing patient support vendors, travel vendors, or specialty service providers.
• Experience in small- to mid-sized biotechnology companies or lean clinical development organizations.

Work Environment

This position is based in a hybrid work environment, with onsite presence 1x per week in South San Francisco.

Job Type & Location

This is a Contract position based out of South San Francisco, CA.

Pay and Benefits

The pay range for this position is $110.00 - $140.00/hr.

Individual compensation offered for this position within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, geographic location, internal equity, and other pertinent job-related factors.

Eligibility requirements apply to some benefits and may depend on your jobclassification and length of employment. Benefits are subject to change and may besubject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:

• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan - Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a hybrid position in South San Francisco,CA.

Application Deadline

This position is anticipated to close on Sep 21, 2026.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 20,000 consultants and 5,000 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500. We are proud to be an Engineering News-Record (ENR) Top 500 Design Firm for our engineering design services and a ClearlyRated Best of Staffing winner for both client and talent service.

The company is an equal opportunity employer and will consider all applications withoutregard to race, sex, age, color, religion, national origin, veteran status, disability,sexual orientation, gender identity, genetic information or any characteristic protectedby law.

If you would like to request a reasonable accommodation, such as the modification oradjustment of the job application process or interviewing process due to a disability,please email [e-mail] for other accommodation options.

San Francisco Fair Chance Ordinance:

Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in thecity and county of San Francisco, we will consider for employment qualified applicantswith arrest and conviction records.

Massachusetts Lie Detector:

It is unlawful in Massachusetts to require or administer a lie detector test as acondition of employment or continued employment. An employer who violates this lawshall be subject to criminal penalties and civil liability.

Use of Artificial Intelligence (AI):

We may use Artificial Intelligence (AI) to support parts of our hiring process,including sourcing, screening, and evaluating candidates. AI helps assess applicationsand qualifications, but final decisions are made by our hiring team. By applying, youacknowledge and agree that your application may be reviewed using AI tools.