Senior Clinical Trial Manager

Actalent; South San Francisco (CA); Hybrid; USD 152,000 - 193,000; Full time

Benefits offered by this job

Medical, dental & vision

401(k) Retirement Plan - Pre-tax and R

Life Insurance

Short and long-term disability

Health Spending Account (HSA)

Transportation benefits

Employee Assistance Program

Time Off/Leave (PTO, Vacation or Sick)

Job summary

Actalent in South San Francisco, CA is seeking a Sr. Clinical Trial Manager to lead oncology studies on a hybrid basis. This contract role oversees trial maintenance, CRO oversight, site closeouts, data quality, and cross-functional coordination with internal teams and external partners.

The ideal candidate has 6+ years in clinical operations in biotech/pharma, sponsor-side oncology trial leadership, and a proven ability to manage CRO performance and study execution from conduct through closeout.

Qualifications

• Bachelor's degree in Life Sciences or related field.
• Minimum 6+ years of clinical operations experience in biotech/pharma.
• Sponsor-side oncology trial management experience.
• Lead oncology trials and manage CROs from sponsor perspective.

Responsibilities

• Lead operational management of oncology trials from conduct to closeout.
• Drive study maintenance, enrollment oversight, site management, data review.
• Oversee vendor relationships including CROs and labs.
• Collaborate with Data Management and CRO teams on data readiness and reporting.
• Ensure compliance with ICH-GCP, FDA/EMA regulations.

Skills

Oncology clinical ops

CRO/vendor management

Communication

Independent leadership

Cross-functional collaboration

Education

Bachelor's degree in Life Sciences

Job description

Job Title: Sr. Clinical Trial Manager Hybrid in South San Francisco, 1x/week 12-month initial contract with potential for extension and conversion

Job Description We are seeking an experienced Sr. Clinical Trial Manager to provide operational leadership for ongoing oncology clinical studies and external research collaborations. This role will be responsible for study maintenance, vendor oversight, site closeout activities, data quality initiatives, and cross-functional coordination across internal and external stakeholders. The ideal candidate is a seasoned sponsor-side oncology clinical operations professional with a proven track record of independently leading studies, managing CROs and vendors, and driving execution through study maintenance and closeout in a biotech environment.

Key Responsibilities

• Lead operational management and oversight of oncology clinical studies from study conduct through closeout.
• Drive study maintenance activities, including enrollment oversight, site management, study metrics tracking, data review, and operational issue resolution.
• Manage large-scale site closeout activities across multiple clinical sites.
• Provide strategic oversight and performance management of CRO partners to ensure timely, high-quality study execution.
• Serve as the primary operational liaison between internal teams, CROs, investigators, laboratories, and external vendors.
• Oversee multiple vendor relationships, including CROs, central/specialty laboratories, and patient support or concierge service providers.
• Collaborate with Data Management and CRO teams to support data cleaning, query resolution, study reporting and database readiness.
• Support operational execution of investigator-initiated trials (IITs), academic collaborations and future clinical research partnerships.
• Identify risks, develop mitigation strategies and proactively communicate study status, challenges and recommendations to cross-functional stakeholders.
• Ensure compliance with ICH-GCP guidelines, applicable regulatory requirements and company SOPs.

Essential Skills

• Bachelor's degree in Life Sciences or a related scientific discipline.
• Minimum 6+ years of clinical operations experience within a biotechnology or pharmaceutical company.
• Direct sponsor-side early phase oncology clinical trial management experience.
• Demonstrated experience serving as the operational lead or study owner for oncology clinical trials (Sr. CTM or comparable level).
• Strong experience managing CROs from the sponsor perspective, including performance oversight, escalation management and accountability.
• Experience managing studies during study conduct, maintenance, data cleaning and closeout phases.
• Strong experience overseeing global early phase studies and multiple vendor relationships.
• Strong understanding of ICH-GCP, FDA, EMA and international clinical trial regulations.
• Excellent communication skills with a demonstrated ability to provide transparent operational updates, appropriately elevate risks and effectively disseminate information across cross-functional teams.
• Ability to work independently and effectively within a cross-functional team environment.

Additional Skills & Qualifications

• Solid tumor oncology experience strongly preferred.
• Experience supporting investigator-initiated trials (IITs), clinical collaborations or externally sponsored research strongly preferred.
• Experience managing patient support vendors, travel vendors or specialty service providers.
• Experience in small- to mid-sized biotechnology companies or lean clinical development organizations.

Job Type & Location

This is a Contract position based out of South San Francisco, CA.

Pay and Benefits

The pay range for this position is $110.00 - $140.00/hr. Individual compensation offered for this position within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, geographic location, internal equity and other pertinent job-related factors. Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan or program terms. If eligible the benefits available for this temporary role may include the following:

Benefits

• Medical, dental & vision
• Critical Illness, Accident and Hospital
• 401(k) Retirement Plan - Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a hybrid position in South San Francisco, CA.

Application Deadline

This position is anticipated to close on Sep 21 2026.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email [e-mail] for other accommodation options.

San Francisco Fair Chance Ordinance

Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records.

Massachusetts Lie Detector

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Use of Artificial Intelligence (AI)

We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying you acknowledge and agree that your application may be reviewed using AI tools.