Senior Clinical Trial Manager

Barrington James; San Francisco (CA); Hybrid; USD 180,000 - 240,000; Full time

Job summary

Barrington James in San Francisco Bay Area is seeking a Senior Clinical Trial Manager (Sr. CTM) to lead complex global studies from start-up through database lock in a hybrid work arrangement (3 days on site).

This permanent/contract opening requires strong leadership and vendor management skills to drive study delivery. The successful candidate will serve as global study lead, mentor CTMs/CRAs, and ensure rigorous regulatory compliance across all phases while coordinating with Medical Affairs

Qualifications

• BS/BA in Life Sciences or related discipline.
• 6+ years of clinical operations experience, including 2+ years at a sponsor company.
• 1+ years as a global study lead.
• Strong familiarity with FDA & ICH/GCP regulations across all stages of clinical development.
• Demonstrated experience managing vendors and CROs directly.
• Heme/onc experience strongly preferred.

Responsibilities

• Independently manage the full scope of study conduct (start-up through database lock) for complex global studies.
• Act as global study lead and lead a Study Management Team (SMT).
• Serve as a technical expert with operational oversight of multiple clinical studies.
• Partner with Medical Affairs/Medical Monitor on site selection, investigator training, and site initiation.
• Oversee external vendors, consultants, and budgets to ensure timely, cost-effective study delivery.
• Identify and mitigate study risks related to data integrity, ethical conduct, and ICH compliance.
• Mentor and develop team members, including CTMs and CRAs.

Skills

Vendor management

CRO management

Leadership

Regulatory compliance

Study start-up

Education

BS/BA in Life Sciences or related discipline

Job description

Title: Senior Clinical Trial Manager (Sr. CTM)

Location: San Francisco Bay Area, CA (Hybrid – 3 days onsite/week)

Position Type: 1 permanent position and 1 contract postion

Our client is a privately held, clinical-stage biopharmaceutical company focused on developing therapeutics to improve the lives of patients with cancer. Founded by proven industry veterans, this is a passionate team building an exciting biotechnology company with a culture defined by caring, ambition, dedication, and teamwork.

• Independently manage the full scope of study conduct (start-up through database lock) for complex global studies (Phase 1 and beyond)
• Act as global study lead and lead a Study Management Team (SMT)
• Serve as a technical expert with operational oversight of multiple clinical studies
• Partner with Medical Affairs/Medical Monitor on site selection, investigator training, and site initiation
• Oversee external vendors, consultants, and budgets to ensure timely, cost-effective study delivery
• Identify and mitigate study risks related to data integrity, ethical conduct, and ICH compliance
• Mentor and develop team members, including CTMs and CRAs

Requirements

• BS/BA in Life Sciences or related discipline
• 6+ years of clinical operations experience, including 2+ years at a sponsor company
• 1+ years as a global study lead
• Strong familiarity with FDA & ICH/GCP regulations across all stages of clinical development
• Demonstrated experience managing vendors and CROs directly
• Heme/onc experience strongly preferred