Senior Clinical Project Manager

Actalent; United States; Remote; USD 147,000 - 200,000; Full time

Benefits offered by this job

Medical, dental & vision coverage

401(k) with employer match

Flexible time off

Parental/maternity leave

Job summary

Actalent is seeking a Senior Clinical Study Project Manager to lead oncology studies and serve as the main client contact. You will coordinate external vendors, manage budgets, and ensure timelines and quality across global trials.

You will collaborate with clinical operations, drive change orders, oversee profitability, and mentor team members while supporting business development and bid defenses as needed.

Qualifications

• Minimum of 7 years of clinical research experience, including at least 4 years in direct project management.
• Bachelor’s degree in science/health; advanced degree preferred.
• Willingness to travel domestically and internationally.

Responsibilities

• Serve as primary contact and escalation point for assigned clinical study projects with client communication.
• Coordinate and oversee all functional services, including external vendors, to meet timelines and budget.
• Manage overall study budget, including change orders and out-of-scope activities.
• Maintain collaboration with clinical operations and assume responsibilities for all clinical activities as needed.
• Manage financial health: profitability, billable hours, and on-time billing/forecasting.
• Develop robust project plans with timelines and risk management strategies.
• Ensure quality management including eTMF readiness and CAPA processes.
• Collaborate with functional operations to support program delivery and review study documentation.
• Establish tracking metrics and KPIs; report to clients and senior management.
• Lead internal and client meetings; set scope/timelines/deliverables.
• Communicate protocol/study issues and deviations; implement corrective actions.
• Conduct presentations to diverse audiences and participate in bid defenses.
• Ensure training implementation and monitor ongoing training compliance.
• Support business development and travel to bid defenses as needed.
• Perform other duties and ensure training and time reporting compliance.
• Provide feedback and mentorship to team members.

Skills

CRO project management

Oncology project management

Budget management

Stakeholder communication

Forecasting

Travel readiness

Education

Bachelor's degree in science/health field

Advanced degree preferred

Tools

eTMF systems

Job description

Responsibilities

• Serve as the primary point of contact and primary escalation point for assigned clinical study projects, ensuring clear, timely, and professional communication with the client.
• Coordinate and oversee all functional services, including external vendors, to ensure delivery against the established project timeline and budget.
• Manage the overall study budget, ensuring projects remain within scope and that any out-of-scope activities are identified early, documented, and handled appropriately, including independently driving change orders to completion and execution with support as needed.
• Maintain close collaboration with clinical operations to support the delivery of clinical activities and, for projects of limited scope, assume responsibility for all clinical activities as needed.
• Manage the financial health of assigned studies, including oversight of project profitability, billable project hours, and compliance with on-time, accurate billing and forecasting to support business objectives.
• Develop robust and comprehensive project plans, including detailed timelines and proactive risk management and mitigation strategies, to guide all aspects of trial execution with consistency and quality.
• Ensure quality management for assigned projects, including maintaining eTMF inspection readiness and implementing quality notification incident forms and/or corrective and preventative action plans to address quality findings.
• Collaborate with all functional operations to support program delivery and review study documentation as necessary to ensure alignment and quality.
• Establish tracking metrics and performance indicators to monitor trial and team progress toward project goals and to identify risks or issues early.
• Prepare clear project status updates and progress reports for clients and Senior management, including reporting on key performance indicators and proposing solutions and improvement opportunities as they arise.
• Lead both internal and client-facing meetings, set expectations for the project team, and ensure alignment on scope, timelines, deliverables, and roles.
• Communicate effectively with clients and internal management to relay protocol and study issues, including any deviations, and implement appropriate actions in response.
• Conduct formal presentations to a wide variety of audiences, including colleagues, investigative site staff, and clients, and participate in bid defense meetings with strong presentation proficiency.
• Ensure implementation of study-specific training in collaboration with functional areas and monitor ongoing training compliance for the duration of each project.
• Support business development and marketing activities as appropriate, including traveling to bid defense and other client meetings as required.
• Perform other duties as assigned by management to support project and organizational objectives.
• Remain compliant with organizational requirements for training, time reporting, and other administrative duties.
• Provide ongoing feedback to functional team members, including contributing to annual performance reviews, and demonstrate leadership through mentorship, escalation handling, and influence without direct authority.

Additional Skills & Qualifications

• Extensive full-service CRO project management experience, with a clear track record of owning end-to-end delivery rather than only functional service provider (FSP) responsibilities.
• Strong oncology project management experience, with priority given to experience in radiopharmaceuticals, CAR-T or cell therapy, and general oncology, in that order.
• Minimum of 7 years of clinical research experience or proven competencies equivalent to this level, including a minimum of 4 years of direct project management experience.
• Bachelors degree in a science or health-related field, or an equivalent combination of education and experience; advanced degree preferred (North America and EU).
• Ability to travel domestically and internationally, including overnight stays, to support client meetings, bid defenses, and study oversight.

Job Type & Location

This is a Permanent position based out of New York, NY.

Pay and Benefits

The pay range for this position is $147300.00 - $200000.00/yr.

Individual compensation offered for this position within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, geographic location, internal equity, and other pertinent job-related factors.

Comprehensive Medical, Dental & Vision Coverage - Generous employer contributions for employees and dependents, national Aetna plans, telehealth access, Delta Dental PPO options, and VSP vision coverage.401(k) with Strong Employer Match - 4% employer match plus immediate 100% vesting through a Safe Harbor plan.Flexible Time Off - Exempt employees receive uncapped "My Time" (MTO), while non-exempt employees receive 20 days PTO annually, paid holidays, personal days, and volunteer time off.Family Planning & Parental Support - Infertility coverage, 8 weeks of paid maternity leave at 100% pay, 4 weeks of paid parental bonding leave, and up to $3,000 in adoption assistance per child.Company-Paid Life & Disability Insurance - Basic life insurance and AD&D up to 1.5x salary (maximum $500,000) plus short- and long-term disability coverage at 60% of pay.Health Savings Account (HSA) Contributions - Employees enrolled in the HDHP receive annual employer HSA contributions of $1,000 (individual) or $1,500 (family/employee-plus coverage).Wellness & Employee Assistance Programs - Free 24/7 support through Headspace, including mental health resources, counseling support, legal/financial assistance, work-life services, and access to over 3,000 wellness resources

Job Type & Location

This is a Permanent position based out of New York, NY.

Application Deadline

This position is anticipated to close on Oct 31, 2026.

Workplace Type

This is a fully remote position.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 20,000 consultants and 5,000 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500. We are proud to be an Engineering News-Record (ENR) Top 500 Design Firm for our engineering design services and a ClearlyRated Best of Staffing winner for both client and talent service.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email [e-mail] for other accommodation options.

San Francisco Fair Chance Ordinance

Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records.

Massachusetts Lie Detector

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Use of Artificial Intelligence (AI)

We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that your application may be reviewed using AI tools.