Senior Clinical Data Manager

Eli Lilly and Company; Indiana (PA); On-site; USD 116,000 - 169,000; Full time

Benefits offered by this job

Company bonus

401(k) plan

Healthcare benefits

Job summary

Lilly seeks a Senior Clinical Data Manager to join Centessa’s clinical programs. This hands-on role reports to the Senior Director of Data Sciences, supporting data delivery across global teams and CROs with autonomy and direct impact in a fast-paced environment.

You will drive data management planning, oversee EDC systems, ensure CDISC/CDASH compliance, and contribute to protocols, SDSPs, and study reports, maintaining regulatory readiness.

Qualifications

• Bachelor’s or Master’s degree with 6+ years of hands-on clinical data management experience.
• Authorized to work in the United States on a full-time basis; Lilly will not sponsor visas.
• Expert knowledge of electronic clinical data systems and multiple vendor EDC platforms.
• Experience managing CROs and technical vendors, with oversight of deliverables and timelines.
• Experience supporting regulatory submissions (Pre‑IND, IND, NDA, and/or BLA) is strongly preferred.

Responsibilities

• Lead planning and execution of clinical data management activities for global development programs.
• Develop and oversee data management strategies and plans including data capture tool design and data processing.
• Establish and maintain clinical data systems and infrastructure including EDC, IRT, ePRO, ECG, and external data sources.
• Drive data standards strategy and CDISC/CDASH compliance for regulatory submissions.
• Partner with internal stakeholders and CRO/tech vendors to align requirements, timelines, and deliverables.
• Provide oversight of vendor platforms and processes for regulatory readiness and quality.

Skills

Project planning

Analytical skills

Interpersonal skills

Cross-functional collaboration

Regulatory knowledge

Education

Bachelor’s/Master’s degree in life sciences

Tools

EDC platforms

Clinical trial tech

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work in 2026.

The Senior Clinical Data Manager will report to the Senior Director of Data Sciences and serve as a hands‑on contributor supporting Centessa’s clinical programs. This role is ideal for an experienced, self‑motivated clinical data professional who enjoys working closely with the data, operating with autonomy, and making a direct impact in a fast‑paced, growth‑oriented environment.

The position partners cross‑functionally to support dependable, high‑quality clinical data delivery in support of key development milestones. The successful candidate brings strong technical expertise, sound judgment, and the ability to collaborate effectively across distributed teams.

This is an opportunity to apply deep clinical data management experience in an entrepreneurial, collaborative culture where attention to detail, ownership, and proactive problem‑solving are highly valued.

Responsibilities

• Lead the planning and execution of clinical data management activities to support global development programs, ensuring high‑quality, timely, and cost‑effective delivery
• Develop and oversee data management strategies and plans, including data capture tool design, data processing, coding, validation, and ongoing data quality oversight.
• Establish and maintain clinical data systems and infrastructure, including the identification, set‑up, testing, and technical oversight of electronic clinical trial technologies (e.g., EDC, IRT, ePRO, ECG, and other external data sources).
• Drive data standards strategy and compliance, providing guidance across the data continuum and ensuring adherence to CDISC/CDASH standards to support regulatory submissions.
• Partner closely with internal stakeholders and external CRO and technology vendors to align on requirements, timelines, deliverables, and performance expectations.
• Provide oversight of vendor technology platforms and processes, ensuring they meet regulatory, quality, and inspection‑readiness requirements for global development programs.
• Develop and manage data management documentation, including data management plans, data transfer plans, and validated automated data flows for internal and external data.
• Monitor timelines, milestones, and deliverables, proactively communicating risks, metrics, and status to cross‑functional teams and leadership.
• Generate and review in‑process data reports and listings to support trial oversight and decision‑making, including safety and data review activities.
• Provide data management input into clinical and regulatory documents, including protocols, protocol amendments, clinical study reports, and statistical analysis plans.
• Ensure data integrity, quality, and regulatory compliance, supporting GCP inspection readiness across all data management domains.
• Contribute to the development of best practices, SOPs, and scalable data management processes to support a growing clinical portfolio.

Minimum Qualifications

• Bachelor’s or Master’s degree with a minimum of 6+ years of hands‑on clinical data management experience in a pharmaceutical or biotechnology environment.
• Qualified applicants must be authorized to work in the United States on a full‑time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.
• Expert knowledge of electronic clinical data systems, including multiple vendor EDC platforms and related clinical trial technologies.
• Proven experience managing and partnering with CROs and technical vendors, including oversight of deliverables, timelines, and quality.
• Strong understanding of regulatory requirements impacting clinical data management, including experience supporting regulatory submissions; Pre‑IND, IND, NDA, and/or BLA experience strongly preferred.
• Demonstrated experience supporting multiple complex clinical studies, including early‑phase (first‑in‑human and proof‑of‑concept) trials; Phase I–III experience preferred. Experience in CNS, oncology, and/or rare disease indications is a plus.
• Excellent project planning and organizational skills, with the ability to prioritize competing demands, manage timelines, and deliver high‑quality work in a fast‑paced environment.
• Highly self‑motivated and detail‑oriented, with strong analytical skills, intellectual curiosity, and a proactive approach to problem solving.
• Exceptional interpersonal, communication, and presentation skills, with the ability to influence and collaborate effectively across cross‑functional teams and with external partners.
• Strong critical and strategic thinking abilities, enabling effective analysis of complex data and operational challenges.

Work Location:

• The Senior Clinical Data Manager role is a based in the US, with occasional travel.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$115,500 - $169,400

Full‑time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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