Senior Clinical Data Manager

100 Eli Lilly and Company; Boston (MA); On-site; USD 116,000 - 169,000; Full time

Benefits offered by this job

401(k) plan

Pension

Vacation benefits

Medical, dental, vision benefits

Flexible benefits

Life insurance

Job summary

Centessa Pharmaceuticals, a Centessa subsidiary of Eli Lilly, is seeking a Senior Clinical Data Manager in the US to lead data management activities for global programs. You will work with cross‑functional teams to ensure data quality, timely delivery, and regulatory readiness.

Reporting to the Senior Director of Data Sciences, you will implement data standards, oversee EDC/IRT/ePRO, and support regulatory submissions with robust data documentation and proactive issue resolution.

Qualifications

• Bachelor’s or Master’s degree in a pharmaceutical/biotech field and 6+ years hands‑on clinical data management experience.
• Experience with electronic clinical data systems and multiple vendor EDC platforms.
• Strong collaboration with CROs, vendors, and cross‑functional teams; familiarity with regulatory submissions.

Responsibilities

• Lead planning and execution of clinical data management activities for global development programs.
• Develop and oversee data management strategies, including data capture tool design and data processing.
• Establish and maintain clinical data systems and infrastructure (EDC, IRT, ePRO, ECG).
• Drive data standards strategy and CDISC/CDASH compliance for regulatory submissions.
• Coordinate with CROs and vendors to align requirements, timelines and quality.
• Oversee vendor platforms to ensure regulatory and inspection readiness.
• Develop data management documentation (plans, transfer plans, data flows).
• Monitor milestones and communicate risks and status to leadership.
• Generate data reports for trial oversight and safety reviews.
• Contribute to clinical/regulatory documents with data management input.
• Ensure data integrity and GXP/regulatory compliance across data domains.
• Help develop SOPs and scalable data management processes.

Skills

Electronic data systems

CRO/vendor management

Regulatory submissions knowledge

Clinical data management

CDISC/CDASH standards

Data quality assurance

Communication skills

Education

Bachelor’s or Master’s degree in life sciences/biotechnology

Tools

EDC platforms

Clinical trial technologies

Data management systems

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life‑changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical‑stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep‑wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical‑stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work® in 2026.

The Senior Clinical Data Manager will report to the Senior Director of Data Sciences and serve as a hands‑on contributor supporting Centessa’s clinical programs. This role is ideal for an experienced, self‑motivated clinical data professional who enjoys working closely with the data, operating with autonomy, and making a direct impact in a fast‑paced, growth‑oriented environment.

The position partners cross‑functionally to support dependable, high‑quality clinical data delivery in support of key development milestones. The successful candidate brings strong technical expertise, sound judgment, and the ability to collaborate effectively across distributed teams. This is an opportunity to apply deep clinical data management experience in an entrepreneurial, collaborative culture where attention to detail, ownership, and proactive problem‑solving are highly valued.

Responsibilities

• Lead the planning and execution of clinical data management activities to support global development programs, ensuring high‑quality, timely, and cost‑effective delivery
• Develop and oversee data management strategies and plans, including data capture tool design, data processing, coding, validation, and ongoing data quality oversight.
• Establish and maintain clinical data systems and infrastructure, including the identification, set‑up, testing, and technical oversight of electronic clinical trial technologies (e.g., EDC, IRT, ePRO, ECG, and other external data sources).
• Drive data standards strategy and compliance, providing guidance across the data continuum and ensuring adherence to CDISC/CDASH standards to support regulatory submissions.
• Partner closely with internal stakeholders and external CRO and technology vendors to align on requirements, timelines, deliverables, and performance expectations.
• Provide oversight of vendor technology platforms and processes, ensuring they meet regulatory, quality, and inspection‑readiness requirements for global development programs.
• Develop and manage data management documentation, including data management plans, data transfer plans, and validated automated data flows for internal and external data.
• Monitor timelines, milestones, and deliverables, proactively communicating risks, metrics, and status to cross‑functional teams and leadership.
• Generate and review in‑process data reports and listings to support trial oversight and decision‑making, including safety and data review activities.
• Provide data management input into clinical and regulatory documents, including protocols, protocol amendments, clinical study reports, and statistical analysis plans.
• Ensure data integrity, quality, and regulatory compliance, supporting GCP inspection readiness across all data management domains.
• Contribute to the development of best practices, SOPs, and scalable data management processes to support a growing clinical portfolio.

Minimum Qualifications

Minimum Qualifications: Bachelor’s or Master’s degree with a minimum of 6+ years of hands‑on clinical data management experience in a pharmaceutical or biotechnology environment. Qualified applicants must be authorized to work in the United States on a full‑time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F‑1 CPT, F‑1 OPT, F‑1 STEM OPT, J‑1, H‑1B, TN, O‑1, E‑3, H‑1B1, or L‑1. Expert knowledge of electronic clinical data systems, including multiple vendor EDC platforms and related clinical trial technologies. Proven experience managing and partnering with CROs and technical vendors, including oversight of deliverables, timelines, and quality. Strong understanding of regulatory requirements impacting clinical data management, including experience supporting regulatory submissions; Pre‑IND, IND, NDA, and/or BLA experience strongly preferred. Demonstrated experience supporting multiple complex clinical studies, including early‑phase (first‑in‑human and proof‑of‑concept) trials; Phase I–III experience preferred. Experience in CNS, oncology, and/or rare disease indications is a plus. Excellent project planning and organizational skills, with the ability to prioritize competing demands, manage timelines, and deliver high‑quality work in a fast‑paced environment. Highly self‑motivated and detail‑oriented, with strong analytical skills, intellectual curiosity, and a proactive approach to problem solving. Exceptional interpersonal, communication, and presentation skills, with the ability to influence and collaborate effectively across cross‑functional teams and with external partners. Strong critical and strategic thinking abilities, enabling effective analysis of complex data and operational challenges.

Work Location

The Senior Clinical Data Manager role is a based in the US, with occasional travel.

EEO Statement

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Employee Resource Groups

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include:

• Africa, Middle East, Central Asia (AMECA)
• Black Employees at Lilly (BE@Lilly)
• Chinese Culture Network (CCN)
• EnAble
• Evolve
• Lilly Indian Network (LIN)
• Organization of Latinx at Lilly (OLA)
• Pride (LGBTQ+ Allies)
• Veterans Leadership Network (VLN)
• Women’s Initiative for Leading at Lilly (WILL)

Compensation

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.

The anticipated wage for this position is $115,500 - $169,400

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).

Benefits

• eligibility to participate in a company-sponsored 401(k)
• pension
• vacation benefits
• eligibility for medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!

#WeAreLilly At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people. We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe! #WeAreLilly