Senior Biochemist - Macrocyclic Discovery Lead

Initial Therapeutics, Inc.

Pasadena (CA)

On-site

USD 140,000 - 210,000

Full time

6 days ago

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Job summary

Lilly's Protomer team seeks a lead biochemist to drive macrocyclic discovery, including assay strategy, lead identification and optimization. You will lead biochemical discussions, design assays, and troubleshoot with biology and protein expression groups to advance preclinical programs.

The ideal candidate has a PhD in biochemistry or related field, with postdoctoral or industry experience, and a strong track record in protein binding assays, automation, and cross-functional collaboration to

Qualifications

PhD in biochemistry, molecular biology, biology, chemical biology or related field, with postdoctoral research experience a plus, and a proven track record of research success.
At least 1 year of post doctoral experience or industry experience in biochemistry/biophysics development.
Expertise in protein expression and characterization techniques, including purification, functional characterization techniques and protein biochemistry methods

Responsibilities

Contribute as a lead biochemist on macrocyclic discovery efforts, providing insight and assay strategy for individual projects in the group.
Lead molecule testing efforts from lead identification to lead optimization and contribute along the way to Phase 1 and beyond
Provide assay development expertise and support for macrocyclic peptide discovery projects
Develop methodologies, protocols and run protein binding assays for characterization of compounds
Characterize complete functionality of protein reagents and contribute insight and oversight into quality and tracking of protein reagents
Learn about and enhance the platform technology efforts at Protomer to accelerate assays and biochemical workflows including automation
Work collaboratively in the group to achieve a common goal while providing independent perspective and scientific rationale to contribute to strategy and execution
Take on dedicated efforts towards targets of high conviction, prioritizing assay efforts both at Protomer and in collaboration with the wider Lilly research organization
Contribute to inventing great medicines by removing barriers, committing to high-quality scientific hypotheses, and accelerating where possible
Keep safety as a top priority at all times, striving toward a proactive safety culture
Work effectively, responsibly and professionally with colleagues at Protomer and across Lilly