Senior Bioanalytical Chemist - Scientist II

RXinsider LTD.; Northern (KY); Hybrid; USD 90,000 - 130,000; Full time

Benefits offered by this job

Medical, Dental & Vision coverage

Life & Disability Insurance

401(k) with company match

Paid vacation and holidays

Job summary

Eurofins Discovery Services North America, LLC seeks a highly skilled scientist to lead LC-MS based ADME/DMPK methods for drug discovery. You will develop and validate analytical methods, perform assays, and troubleshoot instrumentation within a GMP/GxP context.

Join a team delivering services to global pharma/biotech clients, with extensive training, mentoring, and career progression opportunities in a fast-paced environment. Saint Charles, MO based role.

Qualifications

• Direct/ Demonstrated experience with LC-MS in CRO or industry lab.
• Bioanalytical method development for small and/or large molecules.
• Experience with MS-based proteomics and troubleshooting LC-MS systems.
• Demonstrated independence on project teams with time and quality deliverables.
• Experience working in a Quality Management System.

Responsibilities

• Perform LC-MS analyses and ADME/Tox related work in a regulated setting.
• Develop LC-MS methods for ADME/DMPK applications.
• Support project teams with new assay development and method validation.
• Troubleshoot and maintain Mass Spectrometers and HPLC units.
• Ensure data quality and reproducibility across studies.
• Collaborate with internal/external clients and provide training when required.

Skills

LC-MS,

Bioanalytical Method Development

MS-based Proteomics

LC-MS Troubleshooting

Quality Management System

Good communication skills

Education

B.S. with 10 years relevant experience

M.S. with 7 years relevant experience

Ph.D. with 3 years relevant experience

Tools

Sciex Instruments

Thermo High Resolution MS

LC-MS Instruments

Job description

Company Description

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins laboratories work with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate.

The Eurofins network of companies is the global leader in food, environment, pharmaceutical and cosmetic product testing and in agroscience Contract Research Organisation services. It is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organisations. It also has a rapidly developing presence in highly specialised and molecular clinical diagnostic testing and in-vitro diagnostic products.

In over 30 years, Eurofins has grown from one laboratory in Nantes, France to 58,000 staff across a decentralised and entrepreneurial network of 900 laboratories in over 54 countries. Eurofins companies offer a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.

In 2021, Eurofins generated total revenues of EUR 6.72 billion, and has been among the best performing stocks in Europe over the past 20 years.

Job Description

Become your most extraordinary self! Our team is intensely proud to be a major provider of services and products to the drug discovery research industry. Join Eurofins Discovery Services North America, LLC part of the Eurofins Discovery ™ group of companies serving global clients in the Pharma and Biotech industries. Work alongside industry experts and collaborate with team members to directly and positively impact human health worldwide!

We have a philosophy to support work life balance, career progression opportunities and offer many benefits such as formal mentoring programs, tuition reimbursement, extensive career training programs, competitive health benefits, paid time off and 10 annual paid holidays*.

Essential Duties And Responsibilities

• Performs work in a laboratory setting, meeting the physical job requirements of a lab role.
• Conducts production assays primarily in ADME Toxicology Services, but will also support BioTherapeutics Services based on business needs
• Develops Liquid Chromatography- Mass Spectrometry (LC-MS) methods for ADME/ DMPK applications
• Develops analytical methods supporting project teams both internally and externally for new assay development.
• Performs Troubleshooting and Maintenance of Mass Spectrometers and HPLC units. Experience with Sciex® or Thermo High Resolution/ Accurate Mass Instrumentation is a plus.
• Prepares and manages inventory of buffers, reagents, semi-finished and finished goods.
• Provides solutions to more complex problems, identifies and initiates process improvements
• Maintains high data quality and reproducibility.
• Performs data and report QC review within the department, and may support study director.
• Takes ownership of client projects with minimal supervision.
• Supports validation of new methods, and contributes to expansion of service/product line, equipment, and data management systems.
• Understands and complies with requirements for work performed at a GxP site.
• Completes required training and supports 100% of Employee Health and Safety requirements.
• Demonstrates proficiency with care and maintenance of lab equipment and department assets.
• Conducts responsible use of confidential IT and business systems, as required.
• Adheres to department SOPs and documentation requirements, maintains accurate data management and reporting.
• Supports unit goals and demonstrates Eurofins’ competencies, as defined in the job plan.
• Provides training to colleagues and external end users, when required.
• Contributes to scientific community, and site research and development objectives.
• Works effectively in a team environment, under minimum direction, to achieve business production, project timelines, and quality objectives.
• Adjusts work hours and provides cross-functional support to other departments, as required, and maintains accountability in delivering to client needs/timelines.
• Routinely communicates project updates to internal and external clients.
• Performs other duties, as assigned.

Qualifications

Basic Minimum Qualifications (BMQ)

• Direct/ Demonstrated experience with Liquid Chromatography- Mass Spectrometry (LC-MS) in a contract research organization or industry laboratory in one or more of the following areas:
• Bioanalytical Method Development for Small and/or Large Molecules
• Drug Metabolism and Metabolite Identification
• Mass Spectrometry Based Proteomics
• Direct/ Demonstrated experience with Liquid Chromatography- Mass Spectrometry (LC-MS) systems and troubleshooting
• Demonstrated proficiency in contributing independently on a project team with time and quality deliverables
• Good communication and interpersonal skills
• Experience working in a Quality Management System
• Ability to work in the U.S. indefinitely without sponsorship

Education/Experience (BMQ)

• B.S. with 10 years relevant experience
• M.S. with 7 years relevant experience
• Ph.D. with 3 years relevant experience
• Or an equivalent of education and experience

Additional Preferences

• Demonstrated experience with of validation of bioanalytical methods in accordance with regulatory (FDA, ICH, OECD) guidelines
• Experience with liquid handling, automation, solid-phase extraction (SPE), HTS applications, and large-scale screening
• Experience with Sciex® or Thermo® High Resolution/ Accurate Mass Instrumentation and Associated Software is a plus.
• Experience in small team leadership and project management
• Experience in leading and delivering results in R&D or innovation programs

Ability And/or Skills (BMQ)

• Ability to read, write, and interpret documents, such as standard operating procedures and technical reports
• Ability to perform mathematical calculations, statistical analyses, and data interpretation
• Ability to multitask with organization and manage time effectively
• Ability to solve practical problems and troubleshooting skills
• Ability to work in a laboratory setting, according to physical requirements of a laboratory role
• Lab equipment and office computer/software proficiency
• Above average oral and written communication skills
• Demonstrates a positive attitude, capacity for team environment, and exhibits a genuine interest in drug discovery in support of advancing human health
• Ability to develop new methods, and lead research and development projects
• Ability to review and QC release data/reports
• Ability to lead small, informal sub-teams, train, and train new team members
• Ability to conduct mid-size projects with minimal supervision
• Ability to contribute to strategic vision, establishment of new service lines, equipment, and data management systems
• Ability to easily support cross-functional demands

Additional Information

The position is full-time, Monday-Friday, 8:00 a.m.- 5:00 p.m., with overtime as needed. Candidates within a commutable distance of Saint Charles, MO are encouraged to apply.

• Excellent full time benefits including comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays

Eurofins USA Discovery Services is a Disabled and Veteran Equal Employment Opportunity employer.