Senior Associate Scientist, Conjugate Vaccine Research

Vaxcyte, Inc.; San Carlos (CA); On-site; USD 121,000 - 141,000; Full time

Benefits offered by this job

Equity component

Job summary

Vaxcyte, Inc. in San Carlos, CA is seeking a Senior Associate Scientist to lead conjugation of polysaccharides and proteins for novel conjugate vaccines.

You will optimize processes, evaluate physicochemical properties, and work with cross-functional teams to advance programs in a GLP/GMP environment. The role requires 5+ years in industry or 3+ years with an MS, strong analytical skills, and hands-on bioconjugation experience.

Qualifications

• BS or MS in chemistry/biochemistry or related field with industry experience.
• Proficiency in conjugation techniques involving polysaccharides and proteins.
• Hands-on experience with analytical methods for biomolecule characterization.
• Knowledge of covalent coupling and crosslinking chemistries.
• Familiarity with GLP/GMP environments and regulatory standards.

Responsibilities

• Perform conjugation of polysaccharides and proteins to create conjugate vaccines.
• Develop, optimize, and scale conjugation processes for yield and stability.
• Design experiments to evaluate physicochemical properties (size, charge, antigenicity).
• Conduct analytical characterization using HPLC, SEC, MS, SDS-PAGE, UV-Vis, etc.
• Collaborate with Process Development, Analytical Development, and QC teams.
• Document results and maintain lab notebooks per policy and regulatory standards.
• Analyze data, prepare reports, and present findings.
• Stay current with literature and new technologies in conjugate vaccines.

Skills

Conjugation techniques

Analytical characterization

Documentation & reporting

Cross-functional collaboration

Education

BS in Chemistry/Biochemistry

MS in related field

Tools

HPLC

SEC

MS

SDS-PAGE

UV-Vis

Job description

Vaxcyte, Inc. in San Carlos, CA is seeking a Senior Associate Scientist to lead conjugation of polysaccharides and proteins for novel conjugate vaccines.

You will optimize processes, evaluate physicochemical properties, and work with cross-functional teams to advance programs in a GLP/GMP environment. The role requires 5+ years in industry or 3+ years with an MS, strong analytical skills, and hands-on bioconjugation experience.