Conjugation Scientist, Vaccine Research — Impact & Equity

Vaxcyte; San Carlos (CA); On-site; USD 121,000 - 141,000; Full time

Benefits offered by this job

Equity compensation

Comprehensive benefits

Job summary

Vaxcyte is seeking a highly motivated Senior Associate Scientist to join our Research Department in developing conjugate vaccines. Primary focus is conjugation of polysaccharides and proteins with experience in analytical characterization and process development.

The role involves designing experiments, scaling conjugation processes, and collaborating with Process Development, Analytical Development, and Quality Control to advance vaccine candidates, while ensuring compliance with GLP/GMP

Qualifications

• BS degree in Chemistry or Biochemistry with 5+ years of industry experience, or MS with 3+ years of industry experience
• Proficiency in conjugation techniques involving polysaccharides and proteins
• Hands-on experience with analytical methods for characterization of biomolecules
• Knowledge of covalent coupling and crosslinking chemistries
• Familiarity with GLP/GMP environments and regulatory standards
• Prior work involving carbohydrate chemistry or protein modifications

Responsibilities

• Perform conjugation of polysaccharides and proteins using established chemical methods to create conjugate vaccines
• Develop, optimize, and scale up conjugation processes to improve yield, stability, and reproducibility
• Design and execute experiments to evaluate physicochemical properties of conjugated vaccines (size, charge, antigenicity)
• Conduct analytical characterization of conjugates using HPLC, SEC, MS, SDS-PAGE, UV-Vis, and related methods
• Collaborate with cross-functional teams to ensure seamless project progression
• Document results and maintain laboratory notebooks in compliance with policies and regulatory standards
• Analyze data, prepare technical reports, and present findings to stakeholders
• Stay up to date with literature and emerging technologies in conjugate vaccine development

Skills

Conjugation techniques

Biomolecule characterization

Problem solving

Time management

Written and verbal communication

Education

Bachelor's degree in Chemistry/Biochemistry or related field

Master's degree in Chemistry/Biochemistry or related field

Tools

HPLC

SEC

MS

SDS-PAGE

UV-Vis

Job description

Vaxcyte is seeking a highly motivated Senior Associate Scientist to join our Research Department in developing conjugate vaccines. Primary focus is conjugation of polysaccharides and proteins with experience in analytical characterization and process development.

The role involves designing experiments, scaling conjugation processes, and collaborating with Process Development, Analytical Development, and Quality Control to advance vaccine candidates, while ensuring compliance with GLP/GMP