Senior Associate Scientist, Synthetic/Medicinal chemistry

Bristol Myers Squibb; San Diego (CA); On-site; USD 96,000 - 116,000; Full time

Benefits offered by this job

Health Coverage

Wellbeing Programs

401(k) & Disability

Job summary

RayzeBio is seeking a Senior Associate Scientist in Chemistry to support preclinical development of novel radiopharmaceuticals. You will synthesize and design small molecules and peptide analogs to optimize potency, pharmacokinetics, and in vivo efficacy as part of a multidisciplinary team.

The role offers a challenging, rewarding environment at RayzeBio, a Bristol Myers Squibb company, headquartered in San Diego. Collaboration and rigorous documentation are essential in this fast-paced setting.

Qualifications

• BS or MS in Chemistry with strong demonstrable expertise in synthetic organic and medicinal chemistry.
• 3+ years experience (BS) or 2+ years (MS) in a non-academic synthetic chemistry laboratory.

Responsibilities

• Execute multi-step synthetic routes, optimize reaction conditions, isolate and characterize organic compounds.
• Collaborate with colleagues across diverse disciplines.
• Document research activities and present findings clearly.
• Execute experimental plans, troubleshoot synthesis, and optimize lead compounds.

Skills

Small molecule synthesis

Analytical techniques

LCMS/HPLC/NMR

ChemDraw/Scifinder/Reaxys

Lab safety & procedures

Collaboration & communication

Documentation & reporting

AI-enabled productivity

Education

BS or MS in Chemistry

Tools

LCMS

HPLC

NMR

IR spectroscopy

Job description

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients.

Learn more about RayzeBio https://careers.bms.com/rayzebio/

Senior Associate Scientist, Chemistry

Background

RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals

Summary

RayzeBio is looking for a Senior Associate Scientist , to support in the development of novel therapeutics in preclinical stages. Candidates will work as part of a team of scientists to synthesize and design both small molecules and peptide analogs to optimize potency, pharmacokinetics, and in vivo efficacy of potential drug candidates. This position offers a challenging and rewarding work environment within a thriving company.

Job Responsibilities

• Essential duties and responsibilities include the following. Other duties may be assigned.
• Executing multi-step synthetic routes, optimizing reaction conditions, isolation, and characterization of organic compounds (chromatography, NMR, MS, IR spectroscopy).
• Collaborating effectively with colleagues across diverse disciplines.
• Documenting research activities and presenting findings clearly.
• Execute experimental plans, troubleshoot synthetic challenges and contribute to the optimization of lead compounds.

Education And Experience

• BS or MS in Chemistry with strong demonstrable expertise in synthetic organic and medicinal chemistry
• 3+ years experience (BS) 2+ years (MS) in a non-academic synthetic chemistry laboratory.

Skills And Qualifications

• Strong small molecule synthetic skills and knowledge of laboratory techniques and safety, with experience synthesizing peptides a plus.
• Proficiency in compound synthesis techniques, reactions, compound purification, troubleshooting and characterization using methods such as LCMS, HPLC and NMR.
• Familiarity with scientific software such as ChemDraw, Scifinder, and Reaxys.
• Adaptable and flexible, able to handle multiple demands and shifting priorities.
• Self-motivated with good interpersonal skills and ability to work effectively in a fast-paced, collaborative environment.
• Adept in documenting and presenting findings clearly through laboratory notebook, reports, and presentations.
• Uses AI tools to enhance individual productivity and quality of work

Physical Demands

While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 40 pounds. Specific vision abilities required by this job include close vision and distance vision. This is a position that requires working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials.

Work Environment

The noise level in the work environment is usually moderate.

Compensation Overview

San Diego - RayzeBio - CA $95,505 - $115,730

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include

• Health Coverage Medical, pharmacy, dental, and vision care.
• Wellbeing Support Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

Work-life Benefits Include

Paid Time Off

• US Exempt Employees flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

• Eligibility Disclosure The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

RayzeBio and Bristol Myers Squibb

RayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary of BMS; however, RayzeBio will continue to operate as a standalone organization.

Supporting People With Disabilities

BMS and RayzeBio are dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS and RayzeBio will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at [e-mail]. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response.

R1605118 Senior Associate Scientist