Sr. Associate Scientist, Translational Pharmacology

Biopharma Careers; San Diego (CA); On-site; USD 96,000 - 116,000; Full time

Benefits offered by this job

Health Coverage

401(k) plan

Paid Time Off

Flexible work options

Job summary

RayzeBio, a Bristol Myers Squibb company, is seeking a Sr. Associate Scientist Translational Pharmacology to advance radiopharmaceutical therapies from bench to bedside. The role emphasizes in vivo and in vitro pharmacology using CDX/PDX models to assess tumor growth, biodistribution, and efficacy.

You will work in a collaborative, interdisciplinary environment with radioactive isotopes, contributing to experimental design while ensuring animal welfare and safety protocols are followed.

Qualifications

• BS with 4+ years of experience or MS with 2+ years in in vivo pharmacology, translational research, biology, molecular biology, or a related discipline, with hands-on laboratory experience.
• Prior experience in translational or pharmacology projects in industrial or academic settings is preferred.

Responsibilities

• Design and execute in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, and therapeutic efficacy across various treatment modalities.
• Perform essential in vivo procedures including cell culture, tumor cell and PDX fragment implantation, and intravenous dosing.
• Independently analyze and interpret experimental data and present findings at project team meetings and reviews.
• Conduct in vitro experiments post-training, including cell viability and cytotoxicity assays, proliferation analysis, and mechanistic studies such as apoptosis and DNA damage response.
• Maintain meticulous records of procedures and observations per regulatory standards.
• Work with radioactive materials in accordance with safety protocols.
• Collaborate across translational research, medicinal chemistry, and other disciplines to advance pipeline objectives.

Skills

In vivo pharmacology

Cell culture

Animal handling

Surgery

Dosing (IV)

Molecular biology techniques

Data analysis & presentation

Radiation safety compliance

Education

BS with 4+ years or MS with 2+ years in related field

Tools

ELISA

Western blot

Radiopharmacology techniques

Job description

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact, on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/

RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals

Sr. Associate Scientist Translational Pharmacology

Job Description

This laboratory-based role presents an exciting opportunity to advance novel radiopharmaceutical therapies from bench to bedside. The successful candidate will be responsible for conducting in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, and therapeutic efficacy across various pipeline projects. These studies will include the assessment of radiopharmaceutical agents and other therapeutic modalities. In addition to in vivo work, the candidate will perform in vitro mechanistic experiments to explore translational aspects of treatment response. The ideal candidate will have strong hands‑on experience in in vivo and in vitro pharmacology, demonstrate critical thinking, and possess excellent technical problem‑solving skills. A collaborative mindset and enthusiasm for working in interdisciplinary teams are essential.

This role requires the ability and willingness to work with radioactive isotopes.

Job Responsibilities

Essential duties and responsibilities include the following. Other duties may be assigned.

• Design and execute in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, therapeutic efficacy, and durability of response across various treatment modalities, including radiopharmaceutical agents.
• Perform essential in vivo procedures, including cell culture, tumor cell and PDX fragment implantation, surgical modeling of physiological conditions, intravenous dosing, tumor and body weight monitoring, periodic blood collection and necropsy.
• Independently analyze and interpret experimental data, and present findings at project team meetings, departmental reviews, and company-wide forums.
• Conduct in vitro experiments post‑training, including cell viability and cytotoxicity assays, proliferation analysis, mechanistic studies (e.g., apoptosis, DNA damage response), and pathway interrogation using molecular biology techniques.
• Maintain meticulous records of all experimental procedures, data, and observations in accordance with regulatory and internal standards.
• Work with radioactive materials in strict compliance with institutional and federal radiation safety protocols.
• Contribute to experimental design and planning, helping to drive project milestones under tight timelines and dynamic priorities.
• Support translational and in vivo pharmacology efforts under the guidance of project leads, ensuring adherence to animal welfare guidelines and strategic prioritization of studies.
• Collaborate cross‑functionally with teams in translational research, medicinal chemistry, and other scientific disciplines to advance pipeline objectives.
• Assist with laboratory operations, including inventory management, equipment maintenance, and compliance documentation.
• Uses AI tools to enhance individual productivity and quality of work

Education and Experience

BS with 4+ years of experience or MS with 2+ years of experience in in vivo pharmacology, translational research, biology, molecular biology, or a related discipline, with hands‑on laboratory experience.

Prior experience working on translational or pharmacology projects in an industrial or academic setting is preferred.

Skills

• Hands‑on experience with cell culture, tumor cell/fragment implantation, animal handling, surgery, dosing (all routes, with intravenous route required), and necropsy.
• Familiarity and hands‑on experience with cell‑based assays and molecular biology techniques, viability assays, ELISA, western blot etc.
• Excellent written, oral communication, and presentation skills, with the ability to work in a fast‑paced, dynamic, and collaborative environment.
• Strong interpersonal, organizational, and communication skills.
• Familiarity with the drug development process and experience working with interdisciplinary teams.
• Ability to work with radioisotopes, strictly adhering to radiation safety protocols.

Physical Demands

While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 30 pounds. Specific vision abilities required by this job include close vision and distance vision.

This position requires working in a laboratory environment. Protective clothing, gloves, and safety glasses are required while working in the laboratory with radioactive materials.

Work Environment

The noise level in the work environment is usually moderate.

Compensation Overview

San Diego - RayzeBio - CA: $95,505 - $115,730

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job‑related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well‑being and Protection: 401(k) plan, short- and long‑term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include:
• Paid Time Off
• US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part‑time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: T he summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

RayzeBio and Bristol Myers Squibb

RayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary of BMS; however, RayzeBio will continue to operate as a standalone organization.

Supporting People with Disabilities

BMS and RayzeBio are dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail] . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS and RayzeBio will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at [e-mail] . Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response.