Senior Antibody Discovery Scientist

Thecentermemphis; Memphis (TN); On-site; USD 86,320 - 154,960; Full time

Job summary

St. Jude Children’s Research Hospital is seeking a highly motivated candidate with extensive experience in antibody discovery and protein engineering.

The role focuses on display methods (phage, yeast, mammalian) and building diverse libraries, with preference for ML-enhanced approaches. You will design discovery workflows, mine antibody pools with NGS, and support mammalian expression with scalable workflows.

Qualifications

• Bachelor’s degree in relevant scientific area is required.
• Eight (8) years of relevant work experience is required
• Six (6) years of relevant work experience is required with a Master’s degree
• Three (3) years of relevant work experience is required with a PhD
• Experience in antibody discovery and protein engineering preferred
• Experience with in vitro display methods and NGS for antibody discovery preferred

Responsibilities

• Conduct antibody discovery leveraging display methods (phage, yeast, mammalian).
• Develop and optimize protein production platforms for recombinant antibodies and other biologics.
• Perform DNA prep and construct generation for antibody expression; manage ELN data.
• Apply high-throughput workflows and purification using AKTA systems; analyze samples by HPLC-SEC, DSF and related assays.

Skills

Antibody discovery

Protein engineering

Expression & validation

ML-assisted discovery

High-throughput screening

ELN data management

Education

Bachelor’s degree in life sciences

Tools

AKTA chromatography

HPLC-SEC

DSF

NGS

FACS

BLI

epitope binning

Kingfisher

Job description

St. Jude Children’s Research Hospital is seeking a highly motivated candidate with extensive experience in antibody discovery and protein engineering.

The role focuses on display methods (phage, yeast, mammalian) and building diverse libraries, with preference for ML-enhanced approaches. You will design discovery workflows, mine antibody pools with NGS, and support mammalian expression with scalable workflows.