Senior AI-Driven Protein Design Scientist

Illumina; San Diego (CA); On-site; USD 129,000 - 194,000; Full time

Job summary

Illumina in San Diego seeks a Senior Bioinformatics Scientist specializing in AI-enabled protein design and engineering to advance enzyme reagents powering sequencing platforms. This role sits at the intersection of machine learning, structural biology, and protein engineering.

You will design enzymes, analyze high-throughput data, and collaborate with engineers, chemists, biophysicists, and protein scientists to deliver variants with desired properties.

Qualifications

• AI/ML methods applied to protein and enzyme engineering.
• Proficient in Python, C++, or R with strong software development practices.
• Experience with protein sequence/structure modelling and molecular simulations.
• Excellent communication and collaboration across cross-functional teams.

Responsibilities

• Develop bioinformatics tools and pipelines for design/engineering of enzymes.
• Apply AI approaches to predict and optimize enzyme function.
• Evaluate and compare novel computational methods for protein engineering.
• Create reusable templates and dashboards to streamline analyses and decisions.
• Contribute to data capture standards and reproducible workflows.
• Analyze high-throughput data to guide protein optimization.
• Collaborate with engineers, chemists, biophysicists, and scientists to deliver variants.

Skills

AI/ML methods

Python

R

C/C++

Protein modelling

Molecular simulations

Statistical modelling

Communication skills

Team collaboration

Deep learning

Education

Bachelor's degree

Master's degree

PhD

Tools

PyTorch

TensorFlow

JAX

Rosetta

Alphafold

Git

UNIX shell

Job description

Illumina in San Diego seeks a Senior Bioinformatics Scientist specializing in AI-enabled protein design and engineering to advance enzyme reagents powering sequencing platforms. This role sits at the intersection of machine learning, structural biology, and protein engineering.

You will design enzymes, analyze high-throughput data, and collaborate with engineers, chemists, biophysicists, and protein scientists to deliver variants with desired properties.