Scientist- The Geeleher Lab

stjude; Memphis (TN); On-site; USD 86,000 - 155,000; Full time

Job summary

St. Jude in Memphis seeks a Wet-lab Scientist to translate discoveries from PedDep and other large-scale datasets into mechanistic and preclinical studies, with emphasis on neuroblastoma and pediatric solid tumors.

Opportunities include CRISPR screening, drug-response profiling, molecular biology, and in vivo preclinical modeling. The candidate will prioritize and validate therapeutic hypotheses, lead projects, and integrate wet-lab with computational analyses to advance pediatric cancer

Qualifications

• Requires a Bachelor's degree in a relevant scientific area.

Responsibilities

• Coordinates research projects and carries out laboratory experiments utilizing various laboratory techniques.
• Provides input regarding research protocols and experiments. Sets up protocols and assists in developing new laboratory techniques as required.
• Identifies experimental data pertinent to the analysis problem. Processes, organizes and summarizes data, reporting these experimental results as required.
• May draft sections of research manuscripts.
• Provides basic lab operation support to include equipment maintenance and purchasing. Monitors inventory levels and orders lab supplies as needed. Performs calibration of instruments and equipment. Troubleshoots instrument performance and equipment issues.
• Instructs other staff in basic laboratory techniques and procedures.
• Maintains regular and predictable attendance
• Performs other related duties as assigned in order to meet the goals of the department and institution

Education

Bachelor's degree in relevant scientific area

Job description

Join our Team!

The Geeleher Lab tightly integrates wet-bench and computational approaches to improve outcomes for children with cancer, with a particular focus on neuroblastoma and other high-risk pediatric solid tumors. Our hybrid wet-dry lab has led publications in journals including Nature, Genome Biology, the Journal of the National Cancer Institute, and Nature Communications, and is supported by NIH funding, including R01 (NCI renewal recently scored 1st percentile) and R35 awards, as well as institutional funding from ALSAC.

We are closely integrated into the Pediatric Cancer Dependency Map, PedDep, a large multi-institutional collaboration between St. Jude, Dana-Farber, and the Broad Institute. PedDep aims to expand pediatric representation in DepMap and to discover new therapeutic targets, synthetic lethal vulnerabilities, and drug-repurposing opportunities for pediatric cancers.

We are seeking a Wet-lab Scientist to translate discoveries emerging from PedDep and other large-scale functional-genomic, pharmacologic, genomics profiling (e.g. single-cell, spatial gene expression), datasets into rigorous mechanistic and preclinical studies, ultimately aimed at improving outcomes for children with cancer.

The successful candidate will help prioritize, validate, and develop therapeutic hypotheses generated from large cancer datasets, with opportunities to lead projects spanning CRISPR screening, drug-response profiling, molecular biology, cancer genomics, and in vivo preclinical modeling.

Examples of representative recent papers led by wet-lab scientists in our lab (as first author) include:

• https://www.nature.com/articles/s41467-021-26640-x
• https://www.nature.com/articles/s41467-023-43134-0
• https://www.nature.com/articles/s41467-025-57185-y

We also routinely publish tightly integrated wet-lab/computational studies, with recent first authorships by Geeleher Lab members, including:

• https://link.springer.com/article/10.1186/s13059-024-03309-4
• https://www.biorxiv.org/content/10.64898/2026.03.04.709438v2
• https://www.nature.com/articles/s41467-025-66223-8
• https://www.cell.com/cell-genomics/fulltext/S2666-979X(24)00368-9

Job Responsibilities:

• Coordinates multiple aspects of research projects and carries out laboratory experiments utilizing various laboratory techniques, and determines whether additional or other tools or methods are required
• Provides input regarding research protocols and experiments. Sets up protocols and assists in developing new laboratory techniques as required.
• Identifies experimental data pertinent to the analysis problem. Processes, organizes and summarizes data, reporting these experimental results as required. Monitors quality and integrity of recorded information and data
• May draft sections of research manuscripts.
• Provides basic lab operation support to include equipment maintenance and purchasing. Monitors inventory levels and orders lab supplies as needed. Performs calibration of instruments and equipment. Troubleshoots instrument performance and equipment issues.
• Instructs other staff in basic laboratory techniques and procedures.
• Maintains regular and predictable attendance
• Performs other related duties as assigned in order to meet the goals of the department and institution

Minimum Education and/or Training:

Bachelor's degree in relevant scientific area is required.

Minimum Experience:

• Eight (8) years of relevant work experience is required
• Six (6) years of relevant work experience is required with a Master's degree
• Three (3) years of relevant work experience is required with a PhD

Compensation

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Scientist- The Geeleher Lab.

St. Jude is an Equal Opportunity Employer