Scientist, Syntein™ Purification & Physicochemical Properties

Abiologics; Boston (MA); On-site; USD 80,000 - 120,000; Full time

Job summary

A leading biotechnology company seeks a Scientist for Syntein Purification and Physicochemical Properties development. This role involves method development for analyzing Synteins, collaborating with chemists, and utilizing machine learning to enhance the purification process. Ideal candidates will have a strong academic background and hands-on laboratory experience in analytical methods.

Qualifications

• PhD or B.S/M.S in relevant field required.
• Experience in a laboratory setting of 0-2 years (PhD) or 5+ years (B.S/M.S).
• Self-motivated, adaptable to fast-paced environments.

Responsibilities

• Develop methods to analyze and purify Synteins.
• Measure physicochemical properties and report results.
• Integrate machine learning models for drug optimization.

Skills

Troubleshooting chromatographical issues

Analytical method development

Multi-tasking

Laboratory safety procedures

Education

PhD in Chemistry, Chemical Engineering, or Biochemistry

B.S or M.S in Chemistry or related field

Tools

HPLC

Mass Spectrometry

Agilent and/or Shimadzu

Job description

Scientist, Syntein Purification & Physicochemical Properties

Company Overview: Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. We are pioneering the development of Synteins, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional scientists who are passionate about driving therapeutic modality innovation in biotechnology.

Abiologics was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.

Position Summary:

As a key member of Abiologics’ chemistry team, you’ll play a leading role in developing new methods to analyze and purify our Synteins drug candidates. You will work closely with medicinal and peptide chemists to characterize and measure physicochemical properties of our Synteins. You’ll participate in a large machine learning platform initiative aimed at determining optimal physicochemical property parameters for our new drug modality and urgently progressing Synteins toward the clinic

Key Responsibilities:

• Rapid development of analytical and preparative methods to isolate our Synteins with high purity standard.
• Measure physicochemical properties such solubility, stability, and concentration with UV spectroscopy and high-resolution mass spectrometry techniques. Characterization of secondary structure with a variety of analytic techniques
• Integrate, analyze, and report results to guide new compound design in our therapeutic programs.
• Work closely with our computational scientists to generate properties-based machine learning models for our Synteins optimization.
• Build additional capabilities to ensure high-throughput purification and measurement of physicochemical properties of Synteins.
• Develop analytical methods needed during optimization of synthesis or formulation of Synteins.

Qualifications:

• PhD in Chemistry, Chemical Engineering, or Biochemistry with 0-2 years or B.S or M.S in Chemistry or related field with 5 + years of industry experience in a laboratory setting
• Excellent in troubleshooting chromatographical (HPLC) and/or mass spectrometry (MS) issues.
• Experience using Agilent and/or Shimadzu is a plus.
• Experience with solubility assessment and measurement of compound properties a plus.
• Capacity to execute tasks independently to achieve company goals on an established timeline.
• Superb multi-tasking, creativity, adaptability to fast-paced changing environment, and teamwork skills
• Knowledge of, and appreciation for, laboratory safety procedures
• Self-motivated and enthusiasm to work in a dynamic research environment.
• Able to work on-site and attend in-person meetings.

More About Flagship Pioneering

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com .

Flagship Pioneering and our ecosystem companies arecommitted to equal employment opportunityregardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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