Scientist, Solid Tumor CAR-T

Initial Therapeutics, Inc.; Philadelphia (Philadelphia County); On-site; USD 110,706 - 145,303; Full time

Benefits offered by this job

Medical, dental, and vision insurance

401(k) retirement plan with company-m

Paid parental leave

Eight weeks paid time off

Job summary

Legend Biotech in the United States is seeking a Scientist, Solid Tumor CAR-T for its Philadelphia, PA team. The role focuses on advancing CAR-T therapies for solid tumors, driving preclinical development from construct design through in vivo efficacy studies.

The ideal candidate holds a PhD in Immunology or Immuno-Oncology with up to 3 years of postdoctoral experience, and has hands-on experience with primary human T cell isolation, multicolor flow cytometry, and in vivo CAR-T evaluation.

Qualifications

• PhD in Immunology, Immuno-Oncology, or related field.
• Experience with CAR-T or cell therapy research.
• Strong publication record or conference contributions is a plus.

Responsibilities

• Design and execute in vitro CAR-T functional assays.
• Analyze T cell differentiation, activation, and memory subsets.
• Evaluate CAR-T trafficking and tumor infiltration in vivo by flow cytometry and IHC/IF.
• Engineer and maintain cancer cell lines for model development.
• Collaborate across interdisciplinary teams to translate findings.

Skills

CAR-T biology

Flow cytometry

T cell engineering

In vivo models

Education

PhD in Immunology or Immuno-Oncology

Tools

Attune Cytometer

Novocyte

Cytek Aurora

FlowJo

PCR/qPCR

Job description

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking a Scientist, Solid Tumor CAR-T as part of the Research and Development team based in Philadelphia, PA.

Role Overview

We are seeking a highly motivated Scientist to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors. This role is central to our in vivo CAR-T platform and will drive preclinical development from construct design through animal model efficacy studies.

The ideal candidate holds a PhD in Immunology, Immuno-Oncology, or a closely related discipline, with up to 3 years of postdoctoral experience. You are a rigorous scientist who thrives in a fast-paced, collaborative environment and is passionate about translating basic immunology insights into transformative oncology therapies.

Key Responsibilities

• Design and execute in vitro CAR-T functional assays.
• Perform comprehensive phenotypic analysis of T cell differentiation, activation, and memory subsets.
• Evaluate CAR-T cell trafficking and tumor infiltration in vivo using flow cytometry and immunohistochemistry.
• Handling and engineering human and murine T cells as well as various cancer cells.
• Engineering and maintaining various cancer cell lines for model development.
• Analyze and interpret data, troubleshooting, maintain detailed experimental records.

Requirements

• A scientist in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or a closely related field.
• Candidates completing ther PhD within the past 3 years are strongly encouraged to apply.
• Primary human T cell isolation, activation, lentiviral transduction, and expansion is required.
• Multicolor flow cytometry: panel design, data acquisition (e.g., Attune,Novocyte, Cytek Aurora), and analysis (FlowJo).
• Standard molecular biology: PCR/qPCR, lentiviral vector packaging and titration, Western blot.
• Experience with humanized mouse models for in vivo CAR-T evaluation.
• Proficiency in CAR-T cell trafficking studies: IHC/IF of tumor sections, in vivo imaging.
• Familiarity with gene editing tools (CRISPR/Cas9) for cell engineering.
• Experience with in vitro Organoid cancer model establishment and expansion.
• Experience in solid tumor indications (e.g., lung, gastric, or other refractory cancers).
• Contributions to innovation in cell therapy (publications, patents, or conference presentations).

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The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws.

Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles.

Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

Pay Range (Base Pay):

$110,706 - $145,303 USD

Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

Work Authorization & Employment Eligibility

Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

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