Scientist / Senior Scientist, Computational Biology

Arrowhead Pharmaceuticals, Inc; San Diego (CA); On-site; USD 120,000 - 150,000; Full time

Job summary

An innovative biopharmaceutical company is seeking a talented Scientist/Senior Scientist in Computational Biology to join their Translational Genetics team. This role focuses on developing a comprehensive Therapeutic Target and Biomarker Knowledge Database, utilizing large-scale datasets to identify therapeutic opportunities. The ideal candidate will have a PhD and experience in bioinformatics, genetics, or computational biology, with a strong publication record. Join a forward-thinking team dedicated to advancing gene silencing therapies for intractable diseases and make a significant impact in the field of medicine.

Qualifications

• PhD in Bioinformatics or related field with strong publication record.
• Expertise in GWAS, TWAS, and Mendelian randomization required.

Responsibilities

• Conduct GWAS to identify genetic variants associated with diseases.
• Lead initiatives to discover and validate therapeutic targets.

Skills

GWAS

TWAS

Mendelian randomization

Python

R

Bioinformatics

Population genetics

Structural variations

Education

PhD in Bioinformatics

PhD in Computational Biology

PhD in Genetics

Tools

Regenie

SMR-portal

MR-Base

Job description

Scientist / Senior Scientist, Computational Biology

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company focused on developing medicines that treat intractable diseases through gene silencing using RNA interference (RNAi). Our therapies leverage natural gene silencing pathways to address diseases with a genetic basis, offering potential in various therapeutic areas, including liver and lung diseases.

Headquartered in Pasadena, CA, with research teams in Madison, WI, and San Diego, CA, Arrowhead employs innovative, science-driven professionals dedicated to bringing new therapies to patients.

The Position

We are seeking a highly accomplished and motivated Scientist/Senior Scientist, Computational Biologist, to join our Translational Genetics team. The role involves developing a comprehensive Therapeutic Target and Biomarker Knowledge Database to support target and biomarker discovery, utilizing large-scale datasets such as UK Biobank and All of Us. The ideal candidate will have a PhD with at least 2 years of postdoctoral or professional experience and a strong publication record in bioinformatics, genetics, or computational biology.

This role focuses on analyzing datasets to elucidate disease mechanisms and identify therapeutic opportunities, including conducting GWAS, TWAS, and Mendelian randomization studies.

Responsibilities

• Human genetics Driven Therapeutic Target and Biomarker Identification
• Conduct GWAS to identify genetic variants associated with diseases and traits.
• Perform TWAS to link gene expression to disease phenotypes.
• Apply Mendelian randomization to assess causal relationships.
• Investigate structural variations like CNVs and repeat expansions in disease mechanisms.
• Develop genetic landscapes to understand target-disease relationships, efficacy, and safety.
• Collaborate with experimental and clinical teams to design experiments and interpret big biobank data.
• Communicate findings through reports, visualizations, and presentations.
• Scientific Leadership
• Lead initiatives to discover, validate, and prioritize therapeutic targets and biomarkers.
• Stay updated on GWAS, TWAS, MR, transcriptomics, and proteomics advancements, integrating insights into workflows.
• Foster collaborations with biobank and genomics research groups.

Qualifications

• PhD in Bioinformatics, Computational Biology, Genetics, or related field.
• At least 1 year of professional or postdoctoral experience with a strong publication record.
• Expertise in GWAS, TWAS, Mendelian randomization, with experience using tools like Regenie, SMR-portal, MR-Base.
• Proficiency in Python or R for bioinformatics workflows.
• Deep understanding of population genetics, structural variations, and large biobank datasets.
• Excellent communication and collaborative skills.

Preferred

• Experience integrating community data via APIs.
• Background in database development and management.

Salary Range: $120,000 — $150,000 USD

Arrowhead offers competitive salaries and benefits. Applicants must be authorized to work in the US.