Scientist/Senior Scientist, CNS Cell Biology and Light Microscopy

Altos Labs; San Francisco (CA); On-site; USD 127,000 - 282,000; Full time

Job summary

Altos Labs is seeking a Scientist/Senior Scientist focused on CNS cell biology and light microscopy to advance research on brain aging and neurodegeneration. The role involves designing experiments and applying advanced imaging techniques, contributing to our mission of restoring cell health and resilience. Ideal candidates will have a strong background in cell biology and metabolism alongside excellent collaborative skills, working in a diverse and innovative team.

Qualifications

• Thorough understanding of light microscopy principles and cell metabolism.
• Excellent communication and collaboration skills.

Responsibilities

• Provide advanced cell culture and genetic manipulation.
• Independently design and implement light microscopy experiments.
• Engage with cross-research labs to bridge models.

Skills

Cell Culture

Light Microscopy

Metabolic Profiling

Image Analysis

Genetic Manipulation

Education

PhD in Cell Biology, Neuroscience, or Genetics

Tools

Zen

Elements

Arivis

Napari

Fiji

Job description

Scientist/Senior Scientist, CNS Cell Biology and Light Microscopy

Our Mission

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.

Diversity at Altos

We believe that diverse perspectives are foundational to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment.

What You Will Contribute To Altos

As an individual contributor and Scientist at the Bay Area Institute of Science, you will play a key role in advancing Altos' scientific programs about brain aging and neurodegeneration. Working closely with the Frost lab, you will be responsible for designing and implementing innovative experimental approaches using metabolic and light microscopy techniques. This includes developing and utilizing cell types derived from the central nervous system (CNS), applying genetic perturbations to these cells, and employing experimental approaches that include light microscopy and metabolic profiling. The ideal candidate will possess a robust understanding of CNS cell biology, the metabolic shifts characteristic of aging and neurodegenerative diseases, and proficiency in advanced microscopy, image analysis and metabolism techniques. This role reports to Principal Investigator Adam Frost.

Responsibilities

• Provide advanced cell culture, metabolic, and genetic manipulation of iPSC-derived CNS cell types and primary CNS cells.
• Provide independent design and implementation of all phases of light microscopy experimentation, including experimental design, microscope operation, image capture, and quantitative image analysis.
• Engage with cross-Altos research labs to bridge in vitro with in vivo models and to suggest complementary genetic and morphological profiling approaches.
• Stay abreast of advances in light microscopy methods and technologies so that these can be brought to Altos as needed.
• Assist other scientists in the Frost group and beyond in quantitative analysis of microscope images using tools such as Zen, Elements, Arivis, Napari, Fiji, and other software. When appropriate, manage image analysis collaborations with the Computer Vision team.

Who You Are

• PhD in a related field, such as Cell Biology, Neuroscience, Genetics
• Thorough understanding of the principles of light microscopy image visualization, analysis, and processing.
• Demonstrable understanding of cell metabolism, including the impact of metabolism on chromatin and cell fate.
• Excellent communication skills and proven ability to collaborate within a dynamic team.

Preferred qualifications

• Primary CNS cell isolation and culture
• CRISPR-based genetic manipulation of mammalian cells
• Practical experience with the management of terabyte-size microscopy datasets
• Literacy in MATLAB, R, or Python
• Practical experience with cellular image segmentation tools

#LI-NN1

The salary range for Redwood City, CA

• Scientist I, Imaging Technologies: $ 127,500 - $172,500
• Scientist I, Imaging Technologies: $150,000 - $ 205,200
• Senior Scientist I, Imaging Technologies: $ 171,000 - $240,000
• Senior Scientist II, Imaging Technologies:$ 200,000 - $282,000

Exact compensation may vary based on skills, experience, and location.

- Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (bit.ly/eu_uk_privacy_notice )
- This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment.

What We Want You To Know

We are a culture of collaboration and scientific excellence, and we believe in the values of inclusion and belonging to inspire innovation.

Altos Labs provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Altos currently requires all employees to be fully vaccinated against COVID-19, subject to legally required exemptions (e.g., due to a medical condition or sincerely-held religious belief).

Thank you for your interest in Altos Labs where we strive for a culture of scientific excellence, learning, and belonging.

Note: Altos Labs will not ask you to download a messaging app for an interview or outlay your own money to get started as an employee. If this sounds like your interaction with people claiming to be with Altos, it is not legitimate and has nothing to do with Altos. Learn more about a common job scam at https://www.linkedin.com/pulse/how-spot-avoid-online-job-scams-biron-clark/

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