Scientist, Rare Disease Biology

BioSpace; Thousand Oaks (CA); Vor Ort; USD 140.000 - 210.000; Vollzeit

Benefits dieser Stelle

Retirement plan

Stock-based incentives

Flexible work options

Zusammenfassung

Amgen seeks a Scientist in Rare Disease Biology to contribute to discovery and advancement of therapies for rare diseases. You will work with multidisciplinary teams, leveraging iPSC-based human cellular models and integrative analyses to inform portfolio decisions.

The role emphasizes design and execution of in vitro and ex vivo studies, data generation for target validation, and collaboration across biologists, computational scientists, and translational researchers.

Qualifikationen

• PhD or equivalent research training in relevant bioscience field.
• Experience with human cellular models and advanced disease biology is preferred.
• Strong publication record and ability to communicate complex data clearly.

Aufgaben

• Contribute to discovery and advancement of therapies for rare diseases using human cellular models.
• Design, execute, and analyze in vitro and ex vivo studies to test hypotheses.
• Generate high-quality data to support target identification and progression of programs.
• Collaborate with disease biologists, computational scientists, and translational researchers.
• Present findings to project teams and governance forums while maintaining meticulous documentation.

Kenntnisse

Neurobiology

iPSC models

Genetic disease biology

Data-driven approaches

CRISPR

Collaboration

Translational research

Ausbildung

PhD in Immunology, Neurology, Cell Biology, Molecular Biology, Pharmacology, Biomedical Sciences, or related discipline

Master’s degree and 3 years of scientific research experience

Bachelor’s degree and 5 years of scientific research experience

Tools

CRISPR-based approaches

Organoid models

Computational biology tools

Jobbeschreibung

Join Amgen's Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission to serve patients living with serious illnesses drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Position: Scientist, Rare Disease Biology

What you will do

• In this vital role you will contribute to the discovery and advancement of innovative therapies for rare diseases by serving as a core member of multidisciplinary disease-focused research teams. You will apply experimental and data-driven approaches to investigate disease mechanisms, evaluate novel therapeutic targets, and generate insights that inform portfolio decisions. This role offers a unique opportunity to establish and leverage advanced human cellular disease models, including iPSC-based systems, to support discovery efforts across rare diseases.
• Design, execute, analyze, and interpret in vitro and ex vivo studies to investigate disease mechanisms and evaluate therapeutic hypotheses.
• Generate high-quality experimental data to support target identification, validation, and progression of rare disease research programs.
• Investigate molecular and cellular mechanisms associated with transcriptional dysregulation, protein aggregation, cellular stress responses, and impairment of neurological and neuromuscular processes.
• Establish scalable experimental platforms that can support multiple rare disease programs.
• Integrate experimental findings with published literature, human genetics, clinical observations, and other data sources to develop mechanistic insights and inform scientific decision-making.
• Serve as an active member of disease-focused research pods, collaborating closely with disease biologists, computational scientists, translational researchers, and partner functions.
• Participate in scientific discussions, target reviews, and portfolio evaluations by contributing data-driven insights and recommendations.
• Build and maintain productive relationships with internal and external collaborators, including academic partners, foundations, and scientific experts when appropriate.
• Present scientific findings and recommendations to project teams, governance forums, and departmental meetings.
• Maintain accurate documentation and contribute to organizational knowledge-sharing efforts.
• Embrace and contribute to a culture of scientific curiosity, collaboration, continuous learning, and operational excellence.

What we expect of you

Basic Qualifications

• PhD in Immunology, Neurology, Cell Biology, Molecular Biology, Pharmacology, Biomedical Sciences, or related discipline
• OR Master’s degree and 3 years of scientific research experience
• OR Bachelor’s degree and 5 years of scientific research experience

Preferred Qualifications

• Experience in neurobiology, genetic disease biology, or related therapeutic areas.
• Experience studying mechanisms associated with protein aggregation, RNA toxicity, gene silencing, cellular stress responses, or neurological and neuromuscular disease processes.
• Demonstrated expertise developing, maintaining, and utilizing iPSC-derived cellular models.
• Experience with neuronal differentiation, glial cell systems, organoid models, or other advanced human cellular systems.
• Experience working with patient-derived cellular models and genetically engineered cellular systems.
• Familiarity with CRISPR-based approaches, gene editing, or functional genomics technologies is desirable.
• Scientific curiosity and enthusiasm for exploring emerging disease areas and technologies.
• Demonstrated ability to combine experimental and computational approaches to scientific problem-solving.
• Experience working effectively within highly collaborative and matrixed research environments.
• Ability to balance scientific rigor with urgency and adaptability in a dynamic research environment.
• Demonstrated commitment to teamwork, knowledge sharing, and continuous improvement.
• Familiarity with AI-enabled scientific tools, image analysis workflows, computational biology approaches, or advanced data analytics.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.