Scientist, Rare Disease Biology

Amgen; Thousand Oaks (CA); Sur place; USD 120 000 - 180 000; Plein temps

Résumé du poste

Scorpion Therapeutics is seeking a Rare Disease Biology Scientist to discover and advance therapies for rare diseases, with a focus on autoimmune and tissue remodeling mechanisms. The role involves designing in vitro and ex vivo studies, integrating diverse data types, and contributing to translational insights.

The candidate will collaborate across disciplines, develop assays, and present findings to the team, driving program progression in a dynamic research environment.

Qualifications

• PhD in Immunology, Cell Biology, or related field; or Master's with 2+ years, or Bachelor's with 4+ years of research experience.
• Experience with advanced in vitro models and primary human tissues preferred.

Responsabilités

• Design and execute in vitro/ex vivo studies to investigate disease pathways such as immune dysregulation and fibroblast activation
• Generate data supporting target validation and program progression
• Integrate experimental, genetic, and clinical data to develop mechanistic insights
• Contribute to innovative assay development
• Collaborate with multidisciplinary teams and external partners
• Present findings internally.

Connaissances

Fibroblast biology

Immune dysregulation

Data analysis

Cell signaling

Formation

PhD in Immunology, Cell Biology, or related field

Outils

Transcriptomics

Proteomics

Description du poste

Role:

Rare Disease Biology Scientist focused on discovering and advancing therapies for rare diseases, particularly involving autoimmune and tissue remodeling mechanisms.

Responsibilities:

• design and execute in vitro/ex vivo studies to investigate disease pathways such as immune dysregulation and fibroblast activation
• generate data supporting target validation and program progression
• integrate experimental, genetic, and clinical data to develop mechanistic insights
• contribute to innovative assay development
• collaborate with multidisciplinary teams and external partners
• present findings internally.

Requirements:

• PhD in Immunology, Cell Biology, or related field; or Master's with 2+ years or Bachelor's with 4+ years research experience.

Preferred skills:

• expertise in fibroblast biology
• tissue remodeling
• cellular assay design
• and advanced data analysis with transcriptomic or proteomic approaches
• experience working with primary human tissues and advanced in vitro models
• familiarity with AI-driven tools is advantageous.

High-Value:

• focus on autoimmune diseases like Thyroid Eye Disease, tissue remodeling, fibrosis, and inflammatory pathways
• experience in translational research and complex biological data interpretation.

Work Setup:

not specified, likely research laboratory environment; no travel requirements stated.