Scientist, Proteins, Analytical Development

6084-Janssen Research & Development, LLC Legal Entity; Malvern (Chester County); Presencial; USD 110.000 - 150.000; Tempo integral

Resumo da vaga

Johnson & Johnson in Malvern, PA seeks a Scientist, Proteins Analytical Development to lead peptide mapping and LCMS analyses on monoclonal antibodies and biotherapeutics. You will develop and qualify analytical methods, generate robust data, and support IND/IMPD filings with cross-functional teams.

You will operate state-of-the-art LC and MS instruments, learn LCMS software, and design experiments to assess sequence coverage and modifications, contributing to GMP/compliant workflows.

Qualificações

• Advanced degree with LC-MS experience and strong data interpretation.
• Experience with peptide mapping and method development.
• Strong scientific writing, documentation and communication skills.

Responsabilidades

• Operate state-of-the-art LC and MS instrumentation.
• Learn and apply LCMS software for protein analysis.
• Perform LCMS quantification of post-translational modifications.
• Design peptide mapping/MS experiments on antibodies and proteins.
• Support IND/IMPD, BLA filings with data packages.
• Develop test methods and write scientific reports.
• Collaborate in cross-functional teams and project meetings.

Conhecimentos

Analytical reasoning

Biochemistry

Chemistry

Molecular diagnostics

Pharmacogenetics

Written expression

Data quality

Scientific writing

Formação

Master's degree (Biochemistry/related)

Bachelor's degree (Biochemistry/related)

Ferramentas

LC-MS

LCMS software

Descrição da vaga

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com. As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function: Biotherapeutics R&D Job Category: Scientific/Technology All Job Posting Locations: Malvern, Pennsylvania, United States of America

Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Scientist, Proteins, Analytical Development. Purpose: The Therapeutics, Development & Supply (TDS), Proteins Analytical Development (AD) is recruiting for a Scientist who will conduct peptide mapping method development and qualification activities on monoclonal antibodies, bi- and tri-specific antibodies and antibody drug conjugates. You will work and grow in an environment that values innovation, leadership, scientific excellence, urgency, and personal accountability. You will be responsible for:

• Operate state-of-the-art LC and MS instrumentation
• Learn and apply different software packages for LCMS/protein analysis
• Perform LCMS-based quantitation of post-translational modifications
• Design and implement peptide mapping / MS experiments on antibodies and recombinant proteins to assess sequence coverage and sites of modification
• Participate in IND, IMPD, BLA, and other regulatory filings
• Develop test methods, provide documentation and write scientific reports.
• Conduct testing to support analytical development, manufacturing process development, process validations, and manufacturing investigations
• Lead or facilitate technical discussions and participate in cross-functional teams at project-related meetings

• Education: A master’s degree with 5+ years, or a bachelor’s degree with 9+ years of relevant biochemical experience
• Experience and Skills: Required: Proven scientific expertise with extensive hands‑on experience with LC-MS Knowledge of method robustness, method design and familiarity with assay validation parameters Excellent organization, communication, presentation skills and scientific/technical writing skills Proficiency at running and trouble‑shooting assays Able to manage multiple tasks, handle tight timelines and deliver quality data
• Preferred: Experience peptide mapping method development and qualification activities on monoclonal antibodies, bi- and tri-specific antibodies and antibody drug conjugates Excellent interpersonal skills Experience with commercialization of therapeutic proteins An understanding and experience in the application of various GXP concepts Experience preparing reports, protocols and SOPs

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs.

• Analytical Reasoning
• Biochemistry
• Chemistry
• Manufacturing, and Control (CMC)
• Coaching
• Collaboration
• Conducting Experiments
• Data Quality
• Drug Discovery Development
• Molecular Diagnostics
• Patent Applications
• Pharmacogenetics
• Report Writing
• Research Documents
• Scientific Research
• Technologically Savvy
• Written Expression

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at https://www.jnj.com/.

Our Credo calls on us to respect the dignity of every individual and create an environment for all people to thrive.

Throughout the recruitment process - from application through hiring - we are committed to providing reasonable accommodations/adjustments for qualified candidates with disabilities.