Post Doc, R&D Immunology - Population Analytics & Insights

6084-Janssen Research & Development, LLC Legal Entity; Spring House (PA); Presencial; USD 79.000 - 128.000; Tempo integral

Resumo da vaga

Johnson & Johnson Innovative Medicine (JJIM) invites applications for a Postdoctoral Scholar to advance drug target identification and evaluation, aligning priorities with the Immunology therapeutic area. The primary location is Spring House, PA, with a focus on integrating large-scale clinical, genetic, omics, and cell phenotype data to inform drug discovery in R&D.

The role emphasizes innovative computational methods, network models, and AI/ML approaches to mine data and translate findings

Qualificações

• PhD in a quantitative field with a strong biological basis.
• Experience with multi-omic data (RNA expression, proteomics, epigenomics, genetics) at bulk and single-cell level.
• Programming skills and ability to work in a cross-functional scientific team to deliver on objectives.
• Strong communication, organizational and leadership skills with publications and collaborations.

Responsabilidades

• Construct analytic framework by integrating perturbation, ontology and cellular phenotyping with molecular datasets.
• Apply ML methods to link targets to disease states and validate mechanisms.
• Develop network-based models and other novel algorithms to mine biological data.
• Model multimodal data to predict target pathway activity and synergy.
• Analyze phenomic and biobank data to identify targets and biomarkers.

Conhecimentos

PhD in quantitative field with strong生

Bioinformatics/Computational Biology/​

Multi-omics data (RNA, proteomics, ep…

Programming and collaboration

Communication and leadership with pubs

Formação

PhD in quantitative field with strong biological basis

Descrição da vaga

Job Function: Career Programs

Job Sub Function: Post Doc – R&D Product Development

Job Category: Career Program

All Job Posting Locations: Spring House, Pennsylvania, United States of America

Job Description:

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at www.jnj.com Our Credo calls on us to respect the dignity of every individual and create an environment for all people to thrive. Throughout the recruitment process - from application through hiring - we are committed to providing reasonable accommodations/adjustments for qualified candidates with disabilities. Do Not Sell or Share My Personal Information Limit the Use of My Personal Information

Johnson & Johnson Innovative Medicine (JJIM) is recruiting a Postdoctoral Scholar to work within the group (Data Sciences organization) on drug target identification and evaluation to support alignment of priorities with the Immunology therapeutic area. The primary location for this position is Spring House, PA The Data Science Analytics & Insights organization develops innovative solutions using a variety of data sources across multiple different disease\areas. We are looking for a highly motivated and self-driven individual who will creatively analyze large-scale clinical, genetic, omics and cell phenotype data to advance our drug discovery pipeline in R&D. At J&J, we strive to bring in the brightest minds in pursuit of developing effective and safe therapeutics for patients around the globe.

Role & responsibilities:

• Construct an analytic framework by integrating perturbation, ontology and cellular phenotyping with molecular based datasets including genomics, transcriptomics, proteomics, to further enhance target evaluation, and patient stratification.
• Use multiple inference and ML methods linking molecular targets to disease states/characteristics, to associate targets with disease pathways, and to validate predicted mechanisms systematic on-/off-target toxicity predictions.
• These approaches require innovative computational methods such as network-based models, machine learning, and novel algorithmic approaches to mining biological data.
• Provide scientific technical expertise in modeling multimodal data (including genetic, transcriptomics, proteomic and functional data) to predict target pathway activity and synergistic effects.
• Apply or develop a wide variety of statistical modeling and AI/ML methods to analyze phenomic, multiomic and biobank level data to identify targets associated therapeutic with clinical and/or molecular segments and biomarkers associated with immune mediated diseases.
• Provide design and analysis consultation for questions of interest to our Immunology colleagues and facilitate interactions between colleagues across the organization.
• Translate findings from computational analyses to support functional, biological and pharmacological validation.

Job Qualifications:

• Required skills A Ph.D. in a quantitative field with a strong biological basis – Bioinformatics, Computational Biology, Systems Biology, Statistical Genetics, or related fields. Completed PhD program. Experience with multi-omic data (RNA gene expression, proteomics, epigenomics, genetics) at both bulk and single cell level. Working knowledge of databases and analytic approaches associated with gene/pathway ontology, such as network analysis. Proficient in programming and computational skills and demonstrated ability to work with a group of scientists to deliver on objectives in defined timelines. Independent, self-motivated, innovative, and able to excel in a goal-oriented, multifaceted and fast-moving team environment. Outstanding communication, organizational and leadership skills, with a successful track record of publication and collaboration with cross-functional scientific teams.
• Preferred skills Experience working with Immunology projects. Expertise in perturbation data and analysis. Experience with advanced analytical approaches (NLP, ML/AI, LLM) to extracting relevant sources of annotation of cellular states, functions and localization from unstructured data. Experience with predictive models associated with evaluation of target engagement and druggability. Experience with drug discovery and development practices and project support in a large pharmaceutical setting.
• Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs.
• The anticipated base pay range for this position is : $79,000.00 - $127,650.00 Additional Description for Pay Transparency: ubject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits: Vacation –120 hours per calendar year Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year Holiday pay, including Floating Holidays –13 days per calendar year Work, Personal and Family Time - up to 40 hours per calendar year Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year Caregiver Leave – 80 hours in a 52-week rolling period10 days Volunteer Leave – 32 hours per calendar year Military Spouse Time-Off – 80 hours per calendar year For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and Median (sic), we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at https://www.jnj.com/. Our Credo calls on us to respect the dignity of every individual and create an environment for all people to thrive. Throughout the recruitment process - from application through hiring - we are committed to providing reasonable accommodations/adjustments for qualified candidates with disabilities.