Scientist-Principal Scientist, Protein Design & Structure

Superluminal Medicines Inc.; Boston (MA); On-site; USD 80,000 - 120,000; Full time

Benefits offered by this job

Unlimited paid time off

401(k) match program

Comprehensive medical coverage

Job summary

Superluminal Medicines Inc., located in Boston, MA, is seeking an innovative Scientist/Senior Scientist/Principal Scientist to lead GPCR protein engineering efforts. This role requires expertise in membrane protein biochemistry and involves hands-on laboratory work along with scientific leadership in drug discovery projects.

The successful applicant will collaborate with various teams, implement protein expression strategies, and maintain a strong focus on communication and documentation throughout the process.

Superluminal offers comprehensive benefits including medical coverage, 401(k) matching, and unlimited PTO.

Qualifications

• Ph.D. or equivalent in a related field with appropriate experience.
• Deep knowledge of GPCR biology and structure-function relationships.
• Proven expertise in molecular biology techniques.

Responsibilities

• Design constructs for GPCR expression.
• Implement high-throughput protein expression workflows.
• Collaborate with cross-functional teams on drug discovery.

Skills

GPCR biology

Molecular biology

Protein purification

Leadership skills

Communication skills

Education

Ph.D. in Biochemistry, Molecular Biology, or Biophysics

Tools

FPLC

Cryo-EM

Rosetta

Job description

About Superluminal Medicines:

Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company’s platform aims to create candidate‑ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure. We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation.

Position Summary

We are seeking a highly innovative and experienced Scientist / Senior Scientist / Principal Scientist to lead GPCR protein engineering and production efforts. The successful candidate will be a subject matter expert (SME) in membrane protein biochemistry, responsible for developing and implementing strategies to express, purify, and characterize challenging G‑protein coupled receptors (GPCRs) to support structural biology, biophysics, and drug discovery programs. This role involves hands‑on laboratory work and scientific leadership.

Key Responsibilities

• Protein Engineering Strategy: Design, execute, and optimize constructs for GPCR expression.
• Expression & Purification: Drive the development of high‑throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and structural studies (Cryo‑EM).
• Cross‑Functional Collaboration: Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit‑to‑lead and lead optimization.
• Technical Leadership: Serve as a SME on GPCR protein sciences in internal and external project teams; evaluate and implement new technologies.
• Scientific Documentation & Communication: Document experiments in ELN, present data at internal/external meetings, and publish research findings.

Required Qualifications

• Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related field with 2+ years (Scientist), 5+ years (Senior Scientist), or 8+ years (Principal Scientist) of relevant experience; or a master’s or bachelor’s degree in a related field with commensurate industry experience.
• Deep knowledge of GPCR biology and membrane protein structure‑function relationships.
• Proven expertise in molecular biology (cloning, construct design, mutagenesis).
• Hands‑on experience in protein purification of GPCRs using FPLC (affinity, SEC).
• Familiarity with protein stabilization techniques (e.g., antibody fragments, fusion partners, mutagenesis).
• Excellent communication, interpersonal, and leadership skills.

Preferred Qualifications

• Experience with structural biology methods (data collection and processing for Cryo‑EM).
• Experience in laboratory automation in protein sciences & purification.
• Background in computational protein design tools (e.g., Rosetta, AI/ML‑driven prediction).

Benefits

Superluminal offers a comprehensive benefits package that fully covers employees’ annual deductibles and monthly premiums for medical, dental, and vision insurance. The package also includes a 401(k) match program, a Massachusetts transportation subsidy, equity, unlimited paid time off, and both disability and life insurance.

Equal Opportunity Statement

Superluminal Medicines is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership, or civil union status, sex, gender, gender identity or expression, affectional or sexual orientation, disability, veteran or military status or liability for military status.