Scientist, Pharmacokinetics (Onsite)

MSD; Upper Gwynedd Township (Montgomery County); Vor Ort; USD 87.000 - 137.000; Vollzeit

Benefits dieser Stelle

Medical

Dental

Vision

401(k)

Paid holidays

Vacation

Sick days

Zusammenfassung

Merck in the United States is seeking a bioanalytical scientist to execute quantitative methods for small molecules, peptides, and biologics using LC-MS and LBA platforms. You will deliver data for PK/PD and in vitro studies while supporting automated workflows and compliant lab operations.

The role requires a Bachelor’s with 3+ years (or MS with 1–2 years) in analytical chemistry or related field, with experience in LBA for large molecules and proficient LC-MS/MS.

Qualifikationen

• Bachelor’s degree with 3+ years relevant laboratory experience or MS degree (1-2 years relevant experience) in analytical chemistry, pharmaceutical sciences, pharmacology, biomedical, chemical engineering or related field.
• Experience with Ligand Binding Assays (LBA) quantitation of large molecules/biologics.
• Proficient in LC-MS/MS and LBA platforms; capable of hybrid LC-MS/LBA workflows.

Aufgaben

• Develop, validate, and execute quantitative bioanalytical methods using LC-MS/MS, LBA, and hybrid workflows.
• Generate, analyze, and deliver bioanalytical data for PK/PD and in vitro studies.
• Perform manual and automated sample preparation (e.g., protein precipitation, SPE, immunocapture).
• Maintain lab operations and ensure compliance with SOPs and regulatory guidelines.
• Support high-throughput workflows via robotics/automation.

Kenntnisse

LBA with biologics

LC-MS/MS

Teamwork

Communication

Data analysis

Small molecule analysis

Ausbildung

Bachelor’s degree with 3+ years lab experience

MS degree with 1-2 years experience

Tools

Microsoft Office

Jobbeschreibung

Job Description

The department of Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) is seeking a highly motivated bioanalytical scientist to contribute to our drug discovery and early pre-clinical development efforts.

The Scientist will be responsible for execution and troubleshooting of quantitative bioanalytical methods of small molecules, peptides, and large molecules (biologics), utilizing both LC-MS and Ligand Binding Assay (LBA) platforms to deliver high-quality data that drives our pipeline forward.

Key Responsibilities

• Method Execution & Troubleshooting: Develop, validate, and execute robust quantitative bioanalytical methods using LC-MS/MS, Ligand Binding Assays (LBA), and/or hybrid LC-MS/LBA workflows to support discovery and early development programs.
• Data Delivery: Generate, analyze, and deliver high-quality bioanalytical data for PK, PD, and in vitro studies of both small and large molecule therapeutics within established timelines.
• Sample Preparation: Perform manual and automated sample preparation (e.g., protein precipitation, solid-phase extraction, immunocapture/affinity purification for biological matrices).
• Lab Operations & Compliance: Maintain laboratory equipment and ensure all operations strictly adhere to safety, internal SOPs, and regulatory guidelines.
• Automation Integration: Support high-throughput workflows by operating and troubleshooting robotics and automated systems.

Education Minimum Requirement

• Bachelor’s degree with 3+ years relevant laboratory experience or MS degree (1-2 years relevant experience) in analytical chemistry, pharmaceutical sciences, pharmacology, biomedical, chemical engineering or related field.

Required Experience & Skills

• Large Molecule & LBA Experience: Experience with Ligand Binding Assays (LBA) quantitation of large molecules/biologics.
• Teamwork & Interpersonal Skills: Demonstrated ability to collaborate effectively within high-performing, multidisciplinary scientific teams.
• Communication: Excellent written and verbal communication skills, with the ability to present scientific data clearly.
• Technical Proficiency: Proficient in Microsoft Office Suite (Excel, Word, PowerPoint) and standard laboratory software.

Preferred Skills:

• Data Analysis: A basic understanding of statistical analysis and pharmacokinetic principles.
• Small Molecule & Peptide Analysis: Experience with liquid chromatography (LC) and mass spectrometry (MS) for the quantitative analysis of small molecules and/or peptides in biological matrices.

#eligibleforERP

#PRD

Required Skills:

Bioanalysis, Biochemistry, Biotherapeutics, Cell Culture Techniques, Ethical Compliance, GMP Documentation, Good Laboratory Practices (GLPs), Immunoassays, Laboratory Instrumentation, Laboratory Management, Laboratory Safety, Liquid Chromatography-Mass Spectrometry (LC-MS), Pharmaceutical Sciences, Pharmacodynamics, Pharmacokinetics, Pharmacology, Small Molecules

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

The primary location for this posting is:

USA - Pennsylvania - West Point

Where required by law, the compensation range for this role is provided below.

The salary range for the primary location of this role is:

$87,300.00 - $137,400.00

This range reflects the Company's reasonable expectation of the base salary applicable to this role at the time of posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits.

• Medical
• Dental
• Vision healthcare and other insurance benefits (for employee and family)
• Retirement benefits, including 401(k)
• Paid holidays
• Vacation
• Compassionate and sick days

More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

Additional location(s): Please note the salary range above applies to the Primary Location of the position. Where a role has other listed locations, different compensation guidelines may apply. You may find the salary ranges for additional locations below. If the salary range is not listed for the location you are applying to, our Talent Acquisition team will provide further information to you relevant to your location.

Additional location(s) Compensation Information:

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

No

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

Biological matrices

Job Posting End Date:

11/2/2026

*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.