Scientist Lead Discovery & Characterization

Initial Therapeutics, Inc.; South San Francisco (CA); Hybrid; USD 80,000 - 120,000; Full time

Job summary

An established industry player in biotechnology is seeking a passionate Scientist for Lead Discovery & Characterization. This role offers the opportunity to contribute to innovative research in small molecule therapeutics, focusing on protein interactions and binding affinity. You will collaborate with a dynamic team to advance early-stage projects, utilizing cutting-edge technology. The company fosters a culture of growth and inclusivity, ensuring that your contributions will make a significant impact on patient lives. Join this forward-thinking organization and elevate your career while making a difference in the world of healthcare.

Benefits

Comprehensive Employee Benefits Package

Retirement and Savings Plan

Discretionary Annual Bonus Program

Stock-based Long-term Incentives

Award-winning Time-off Plans

Flexible Work Models

Qualifications

• PhD or relevant experience in small molecule therapeutics.
• Experience with SPR kinetics and binding affinity characterization.

Responsibilities

• Characterize protein small molecule interactions using SPR.
• Independently conduct laboratory experiments and analyze data.

Skills

Small Molecule SPR Kinetics

Binding Affinity Characterization

Excellent Communication Skills

Collaborative Team Environment

Education

PhD in relevant field

Master's degree

Bachelor's degree

Tools

Cytiva Biacore Instruments

Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist - Lead Discovery & Characterization

What you will do

Lets do this. Lets change the world. In this vital role you will be a member of a team providing support for the early-stage pipeline of small molecule (SM) therapeutics

• Characterize protein SM interactions using SPR with Cytiva Biacore instruments

• Work on assay development, hit characterization, kinetic and affinity characterization of ternary complex formation, studies to support MOA.

• Independently devise and implement creative scientific research through conducting laboratory experiments, planning detailed procedures for defined projects including timelines, milestones, methodological approaches, expected results and necessary resources; reviewing, analyzing, and interpreting scientific data and results; providing regular updates, documentation, and/or communication on project results; collaborating with other scientists and keeping current with field of expertise, including literature and technology development

• Additional responsibilities may include advising supervisors and colleagues in areas of expertise; participating in national and international scientific meetings; providing scientific results that support the generation of publications, patents, or regulatory submissions and mentoring research associates and laboratory assistants

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a scientist with these qualifications.

Basic Qualifications:

• PhD & relevant experience

OR

• Master's degree and 2 years experience

OR

• Bachelor's degree and 4 years experience

AND

• Experience with small molecule SPR kinetics and binding affinity characterization

Preferred Qualifications:

• Clear understanding of binding experiments as well as a general knowledge of related methods and data fitting computer applications.

• Excellent communication skills (both written and oral)

• Able to work in a collaborative team environment with (at times) tight timelines that must be met.

• Attendance to one of David Myszkas label free workshops preferred but not required

• Proven track record of academic accomplishments (i.e., peer-reviewed publications and/or patents)

• Demonstration of good lab practices, with particular attention to safety

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans

• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

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Application deadline

Amgen anticipates accepting applications until 5/10/2025; however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.