Scientist II/Senior Scientist, Analytical Development

ZipRecruiter; San Diego (CA); On-site; USD 130,000 - 170,000; Full time

Job summary

A leading biotechnology company seeks a Scientist II/Senior Scientist in Analytical Development. This role involves developing analytical methods for mRNA-based lipid nanoparticles, supporting product characterization, and collaborating with research teams. Candidates with a PhD or relevant industry experience are encouraged to apply, as they will contribute significantly to innovative therapeutic developments.

Benefits

Performance bonus

Employee Stock Option Program

401(k) with employer match

Medical, Dental, Vision coverage

Flexible Spending Account (FSA)

Paid Time Off (PTO), Holidays, Sick Days

Onsite amenities

Qualifications

• PhD with 2-4 years, or M.S. with 5-7 years, or B.S. with 8+ years of relevant experience.
• Technical expertise in LC/CE characterization of large molecules.
• Experience drafting and reviewing technical documents.

Responsibilities

• Develop and optimize analytical methods for characterizing tLNP drug products.
• Lead internal development through pre-validation of novel analytical methods.
• Mentor and train members of the analytical development team.

Skills

Analytical methods development

Communication skills

Collaboration

Education

PhD

M.S.

B.S.

Tools

HPLC

LC-MS

CE

iCIEF

ELISA

Job description

Job Description

About Capstan Therapeutics

Capstan is a biotechnology company with a mission to multiply the therapeutic possibilities for patients by developing targeted in vivo RNA technologies. Our proprietary CellSeeker tLNP platform technology is composed of novel LNPs conjugated with a recombinant protein binder, such as a monoclonal antibody. tLNPs are designed to deliver payloads, including mRNA or gene editing tools, capable of reprogramming specific cell types in vivo. Capstan’s CellSeeker technology has the potential to generate transformative therapies with possible applications across a broad range of disease areas, including autoimmune disorders, oncology, fibrosis, and monogenic blood disorders.

The Opportunity

We seek a Scientist II/Senior Scientist, Analytical Development to join an experienced, fast-paced, and collaborative team. This position will be primarily responsible for developing and optimizing analytical methods supporting the biophysical characterization of mRNA-based targeted lipid nanoparticles (tLNPs) for Capstan’s pipeline. Working closely with the technology development and research teams, this position will support process/product understanding, support expansion of the tLNP platform, contribute to product investigations, and build phase-appropriate protein and tLNP QC and extended characterization methods.

Responsibilities & Duties:

1. Develop and optimize analytical methods for characterizing tLNP drug products, focusing on protein, protein conjugate, and lipid nanoparticle analysis
2. Design and execute routine and non-routine analysis supporting process/platform development, stability, and product characterization. Support analytical investigations into deviations and OOS/OOT results
3. Lead internal development through pre-validation of novel analytical methods to characterize tLNP components and product, including but not limited to HPLC, LC-MS, CE, iCIEF, ELISA, and/or plate-based assays
4. Support method transfer to and qualification at CDMOs
5. Mentor and train members of the analytical development team
6. Clearly communicate findings through presentations and data summaries
7. Author, review, and approve standard operating procedures, protocols, and reports

Requirements/Qualifications:

• Generally met with a PhD with 2-4 years, M.S. with 5-7 yrs, or B.S with 8+ years of relevant industry experience
• Technical expertise with LC/CE characterization of large molecules, such as antibodies/ADCs, mRNA, and/or gene therapy vectors
• Experience with extended characterization and release/stability testing of biologics and/or lipid nanoparticles
• Experience drafting and reviewing technical documents, such as SOP, technical reports, and qualification/stability protocols
• Experience with method qualification and transfer
• Strong communication skills, both written and verbal, with a demonstrated capacity to thrive in collaborative, team-driven environments

Salary & Benefits:

• Salary range is $130,000 – $170,000/year
• Performance bonus
• Employee Stock Option Program
• 401(k) Program including an employer matching contribution
• Medical, Dental, Vision coverage
• Short and Long Term Disability coverage
• Flexible Spending Account (FSA)
• Optional Dependent Care Account
• Paid Time Off (PTO), Holidays, Sick Days
• Employee Assistance Program
• Onsite amenities including kitchens, gym, and discounts
• Fun team environment with employee events

If you are interested in hearing more, reach out to us. We believe that each team member will impact and improve the lives of those we work with, and those we work for—our patients.

Capstan Therapeutics, Inc. is an equal opportunity employer and does not discriminate against applicants or employees on the basis of race, creed, ancestry, medical condition, disability, genetic information, or any other characteristic protected by law.

In accordance with applicable laws, applicants and employees with disabilities are eligible for reasonable accommodations. Please contact [e-mail] if needed.

Unsolicited resumes sent to Capstan from recruiters do not constitute a relationship or obligation. External recruiters and agencies are asked not to contact or present candidates directly.

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