Scientist II / Senior Scientist, ADME

Immunomeinc; Bothell (WA); On-site; USD 150,000 - 204,000; Full time

Job summary

Immunome, Inc. in Washington state is seeking an experienced Senior Scientist II in ADME to lead the design and execution of nonclinical PK/PD and ADME programs, shaping candidate selection and regulatory submissions.

You will collaborate with cross-functional teams to integrate ADME insights into program strategy, mentor scientists, and stay current with evolving regulatory expectations.

The role offers a competitive salary and growth within a clinical-stage oncology portfolio leveraging ADCs.

Qualifications

• PhD in a relevant discipline with 0–3 years of industry experience in ADME/PKPD and ADME.
• Experience with ADCs required; additional experience with small molecules, monoclonal antibodies, or other modalities preferred.
• Hands-on expertise in PKPD modeling, PK/TK analysis, and study design.
• Knowledge of both non-regulated and regulated bioanalysis.

Responsibilities

• Perform modeling and simulation, analyze PKPD and PK/TK data, and provide clear interpretation to inform program decisions.
• Design and execute stage-appropriate PKPD and ADME studies to support candidate selection, clinical development, and regulatory submissions.
• Collaborate with cross-functional teams to ensure integration of ADME considerations into program strategy and timelines.
• Participate in Translational Sciences and Development team activities, contributing scientific expertise in ADME.
• Represent the ADME function at internal and external meetings, communicating timelines, data, and implications effectively.
• Maintain awareness of evolving best practices and regulatory expectations in ADME sciences.

Skills

Problem-solving skills

Excellent communication

Collaborative work style

Education

PhD in a relevant discipline

MS with 5+ years relevant industry experience

Job description

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

TheScientistII/ Senior Scientist,ADMEwillcontributetothedesignandexecutionofnonclinical

Responsibilities

• Performmodelingandsimulation,analyzePKPD andPK/TKdata,andprovideclear interpretation to inform program decisions.
• Design and execute stage-appropriate PKPD and ADME studies to support candidate selection, clinical development, and regulatory submissions.
• Collaborate with cross-functional teams to ensure integration of ADME considerations into program strategy and timelines.
• Participate in Translational Sciences and Development team activities, contributing scientific expertise in ADME.
• Represent the ADME function at internal and external meetings, in collaboration with senior scientists, communicating timelines, data, and implications effectively.
• Maintain awareness of evolving best practices and regulatory expectations in ADME sciences.

Qualifications

• PhDinarelevantdisciplinewith0–3yearsofindustryexperienceinADCPKPDandADME,orMS with 5+ years relevant industry experience.
• Experience with ADCs required; additional experience with small molecules, monoclonal antibodies, or other modalities preferred.
• Hands-on expertise in PKPD modeling, PK/TK analysis, and study design.
• Knowledge of both non-regulated and regulated bioanalysis.

Knowledge and Skills

• Strongproblem-solvingskills with theabilityto managemultipleprojectsinafast-pacedenvironment.
• Excellent communication skills, with the ability to present complex scientific data clearly to diverse audiences.
• Collaborative approach with the ability to work across disciplines to achieve program goals.
  

Level andcompensationwillbecommensuratewith relevant experience.

Washington State Pay Range

$149,930 — $203,961 USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).