Scientist II, Bioassay Development

BioSpace; South San Francisco (CA); On-site; USD 82,000 - 158,000; Full time

Job summary

A leading biopharmaceutical company is seeking a Scientist II in Bioassay Development to support drug development in oncology and immunology. This role involves developing bioassays essential for therapeutic antibody development and includes responsibilities in cross-functional collaboration and regulatory documentation.

Benefits

Comprehensive benefits package

Short-term incentive programs

Paid time off

Medical/dental/vision insurance

Qualifications

• Typically requires 7+ years (BS) or 5+ years (MS) of relevant industry experience.
• Experience with ELISA and flow cytometry for binding potency assays is essential.
• Experience with biological therapeutics preferred.

Responsibilities

• Develop and optimize bioassays for complex biologic drugs.
• Collaborate with various teams for molecular characterization.
• Author technical documents to facilitate regulatory submissions.

Skills

Cell-based assays

Binding potency assays

Mammalian cell culture

Data analysis

Education

Degree in biology, biochemistry, or related field

Tools

PRISM

Softmax Pro

Job description

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Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onX,Facebook,Instagram,YouTube,LinkedInandTik Tok.

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onX,Facebook,Instagram,YouTube,LinkedInandTik Tok.

Job Description

The Bioassay Development group at AbbVie South San Francisco, CA is seeking a Scientist II to support the development and evaluation of newly discovered oncology and immunology drugs and existing clinical candidates, including antibody therapeutics, antibody-drug conjugates (ADCs), multi-specific biologics, and other complex biologic modalities.

The selected candidate will join the Biologics Analytical Research and Development team, a group of highly experienced scientists and managers who have directly enabled the development and IND submissions of 20+ novel biologic drugs and the successful filing of several BLAs. You will have unique and diverse exposure to a significant breadth and depth of drug development activities, numerous cross-functional interactions, and opportunities to grow and develop in your scientific career.

Responsibilities

In this lab-based role, your major responsibilities will include:

• Development and optimization of complex cell-based functional assays (bioassays) and target-binding potency assays critical for the development of therapeutic antibodies, antibody-drug conjugates (ADCs), multi-specific biologics, and novel/complex antibody variants.
• Collaborate with Analytical Research and Development teams to elucidate structure/function molecular characterization and interact cross-functionally with teams from Discovery, CMC, QC, and more.
• Perform potency testing and characterization to support drug development activities and IND submissions.
• Qualify/validate/transfer potency methods to external partners and author technical documents (e.g. test methods, protocols, and reports) to enable regulatory submissions.
• Develop new techniques, explore new approaches and technologies, perform troubleshooting and optimization experiments, and present your work to various cross-functional teams.
  
  
  

Qualifications

• Degree in biology, biochemistry, cell/molecular biology, or a related field with typically 7+ years (BS) or 5+ years (MS) of relevant industry experience
• Demonstrated experience with current binding potency assay approaches, such as ELISA, flow cytometry, and/or other binding potency assay platforms (i.e. TR-FRET, Octet, etc)
• Demonstrated experience with current cell-based assay methodologies, such as cytotoxicity assays, reporter gene assays, proliferation assays, primary cell-based assays, and/or effector function activity assays (i.e. ADCC, CDC, etc)
• Experience performing cell-based assays, mammalian cell culture, and/or target binding potency assays, preferably in a bioassay development group within a Chemistry Manufacturing and Controls (CMC) organization.
• Experience using PRISM, PLA, Softmax Pro, or similar data analysis software.
• Direct experience with biologics, monoclonal antibodies, and/or protein therapeutics is a plus
• Direct experience with potency assay optimization and troubleshooting is a plus.
• Proven ability to work in a highly collaborative, cross-functional scientific environment.
• Strong verbal and written communication skills.
• Demonstrated abilities to quickly learn new skills, think independently, and work collaboratively in teams.
• The ideal candidate will be hard-working, self-motivated, detail-oriented, highly organized, and able to adapt quickly to changes.
• This position is an on-site role in a lab-based function. To be successful, candidates must enjoy and thrive in an on-site, highly collaborative lab environment with daily face-to-face cross-functional interactions between scientists.
  
  
  

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• This is an on-site role based in AbbVie's South San Francisco location.
• The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at the time of this posting based on the job grade for this position. Individualcompensation paid within this range will depend on many factors including geographic location, and we may ultimatelypay more or less than the posted range. This range may be modified in the future.Salary: $82,500 - $157,500
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/visioninsurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.
  
  
  

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, and determinable.The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html

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