Scientist - II

INTELLISWIFT INC; Boston (MA); On-site; USD 70,000 - 100,000; Full time

Job summary

A leading company located in Boston seeks a Scientist - II (Associate) to develop and run quantitative biochemical and biophysical assays. The ideal candidate will have a degree in biochemistry or biophysics with relevant industry experience. Responsibilities include conducting studies to optimize small molecule ligands and elucidating their interactions with target proteins.

Qualifications

• 1-5 years industry experience for BS/BA or 1 year for MS.
• Experience with assay development and compound profiling preferred.

Responsibilities

• Develop biochemical and biophysical assays for small molecule ligands.
• Conduct studies on ligand interaction and mechanisms of action.

Skills

Knowledge of biochemistry

Knowledge of biophysics

Molecular biology

Biochemical techniques

Biophysical techniques

Team player

Oral communication

Written communication

Basic computer proficiency

Education

BS/BA or MS in biochemistry, biophysics or related discipline

Tools

Automated liquid handlers

TIBCO Spotfire

Excel

PowerPoint

Job description

Job Title: Scientist - II (Associate)
Duration: 12 months, 40 hrs / week
Location: Boston, MA 02115

Qualifications:
Education Requirement:
• BS/BA degree in biochemistry, biophysics or a related discipline with a minimum of 1-5 years industry experience; or a MS degree in biochemistry, biophysics or a related discipline with 1 or more years of industry experience, preferably with a focus on assay development and compound profiling within a drug discovery environment.

Required Skills:
• Candidate should have basic knowledge of biochemistry, biophysics and molecular biology
• Candidate should have prior experience with basic biochemical and/or biophysical techniques
• Candidate should be highly motivated, driven, and willing to take the initiative to learn new scientific methodologies
• Candidate should be a strong team player
• Candidate should have excellent oral and written communication skills
• Candidate should be comfortable using a PC computer and proficient in Windows-based operating systems and basic applications, such as spreadsheets and databases
• Experience in the use of automated liquid handlers such as Echo, Bravo, Biomek, or Hamilton and data analysis and presentation software such as TIBCO Spotfire, Excel and PowerPoint.

Preferred Attributes:
• Proven ability to independently design, develop and implement biochemical and biophysical screening assays using detection modalities such as: TR-FRET, FP, LC-MS, radiochemical, surface plasmon resonance (BIAcore), fluorescence-based thermal shift (TdF), and/or isothermal titration calorimetry (ITC).
• Hands-on experience performing steady-state and transient-state kinetic experiments to study enzymes and inhibitors.
• Direct experience in recombinant protein expression using bacteria, insect (baculovirus) and/or mammalian cell-based systems and purification using automated chromatographic separation systems.

Responsibilities:
• Develop and/or run quantitative biochemical and biophysical assays to support identification, characterization, and optimization of small molecule ligands from high throughput screening campaigns and medicinal chemistry efforts.
• Conduct biochemical and biophysical studies to elucidate the modes of ligand interaction and mechanisms of action on target proteins.

About the company

Intelliswift has been a top IT & Software solutions company in USA which provides end-to-end IT services and building strong digital foundations

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